N-Ethyl-N-isobutyl-hydrazin | 67398-35-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-Ethyl-N-isobutyl-hydrazin
• 英文别名: 1-Ethyl-1-isobutylhydrazin；1-Ethyl-1-isobutylhydrazine；1-ethyl-1-(2-methylpropyl)hydrazine
• CAS: 67398-35-0
• 化学式: C₆H₁₆N₂
• 分子量: 116.206
• InChiKey: SRPRMXWUMUHGED-UHFFFAOYSA-N

物化性质

• 保留指数：
  829

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] METHODS AND COMPOUNDS FOR TREATING DISORDERS<br/>[FR] PROCÉDÉS ET COMPOSÉS POUR TRAITER DES TROUBLES
  申请人：FOGHORN THERAPEUTICS INC

  公开号：WO2019152440A1

  公开（公告）日：2019-08-08

  The present invention relates to methods and compositions for the treatment of BAF-related disorders such as cancers and viral infections.

  本发明涉及用于治疗与BAF相关的疾病，如癌症和病毒感染的方法和组合物。
• [EN] SMALL MOLECULE FURIN INHIBITORS FOR TREATING INFECTIOUS DISEASES<br/>[FR] INHIBITEURS DE FURINE À PETITES MOLÉCULES POUR LE TRAITEMENT DE MALADIES INFECTIEUSES
  申请人：BP ASSET V INC

  公开号：WO2021097009A1

  公开（公告）日：2021-05-20

  Provided herein are methods of treating a viral infection in a subject in need thereof, comprising administering to the subject a compound of Formula (I), or a pharmaceutical composition comprising Formula (I). Further provided herein are methods for inhibiting the replication of a virus (e.g., a togaviridae family virus (e.g., an alphavirus (e.g., Chikungunya virus, Eastern equine encephalitis, Mayaro virus, Venezuelan equine encephalitis virus, Western equine encephalitis)), a filoviradae family virus (e.g., a Marburg virus (e.g., Marburg virus, Ravn virus)), human respiratory syncytial virus (i.e., human orthopneumo viru s ), a flavivirus (e.g., dengue virus, Usutu virus, Japanese encephalitis virus, Powassan virus, yellow fever), a paramyxoviridae family virus (e.g., an orthoparamyxovirinae virus (e.g., a henipavims (e.g., Nipah virus), a morbillivims (e.g., measles morbillivirus))) in a subject in need thereof. Also provided herein are methods for treating and/or preventing a disorder due to a microbial toxin (e.g., due to P. aeruginosa exotoxin A, Clostridium septicum alpha-toxin, diphtheria toxin(s), shiga toxin(s)) in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula (I), or a pharmaceutical composition comprising a compound of Formula (I) as described herein. Also provided are pharmaceutical compositions and kits including a compound of Formula (I) for use in the treatment and/or prevention of a viral infection in a subject in need thereof.

  本文提供了治疗需要的受试者体内病毒感染的方法，包括向受试者投与化合物I的方法，或者包含化合物I的药物组合物。本文还提供了用于抑制病毒复制的方法（例如togaviridae家族病毒（例如alphavirus（例如，基孔肯雅病毒，东部马脑炎，马雅罗病毒，委内瑞拉马脑炎病毒，西部马脑炎）），filoviradae家族病毒（例如马尔堡病毒（例如，马尔堡病毒，拉文病毒）），人类呼吸道合胞病毒（即人类正交病毒），黄病毒（例如登革病毒，乌苏图病毒，日本脑炎病毒，波瓦松病毒，黄热病），paramyxoviridae家族病毒（例如正参数病毒（例如蝙蝠病毒（例如，尼帕病毒），麻病毒（例如，麻疹麻病毒）））的方法。本文还提供了治疗和/或预防由微生物毒素引起的紊乱的方法（例如由P. aeruginosa外毒素A，肠炎类固醇α-毒素，白喉毒素，志贺毒素引起的紊乱）的方法，包括向受试者投与化合物I的治疗有效量，或者包含本文所述的化合物I的药物组合物。还提供了包含化合物I的药物组合物和配套用品，用于治疗和/或预防需要的受试者体内的病毒感染。
• [EN] COMPOUNDS AND USES THEREOF<br/>[FR] COMPOSÉS ET LEURS UTILISATIONS
  申请人：FOGHORN THERAPEUTICS INC

  公开号：WO2020160196A1

  公开（公告）日：2020-08-06

  The present invention relates to compositions and methods for the treatment of BAF-related disorders, such as cancers and viral infections.

  本发明涉及用于治疗与BAF相关的疾病，如癌症和病毒感染的组合物和方法。
• [EN] COMPOUNDS AND USES THEREOF<br/>[FR] COMPOSÉS ET UTILISATIONS ASSOCIÉES
  申请人：FOGHORN THERAPEUTICS INC

  公开号：WO2022109426A1

  公开（公告）日：2022-05-27

  The present disclosure features compounds useful for the treatment of BAF complex-related disorders.

  本公开涉及用于治疗BAF复合物相关疾病的化合物。
• METHODS AND COMPOUNDS FOR TREATING DISORDERS
  申请人：Foghorn Therapeutics Inc.

  公开号：US20210009568A1

  公开（公告）日：2021-01-14

  The present invention relates to methods and compositions for the treatment of BAF-related disorders such as cancers and viral infections.