2-(2-(Methylamino)propyl)benzofuran | 806596-15-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: 2-(2-(Methylamino)propyl)benzofuran
• 英文别名: 1-(1-benzofuran-2-yl)-N-methylpropan-2-amine
• CAS: 806596-15-6
• 化学式: C₁₂H₁₅NO
• 分子量: 189.25
• InChiKey: ANJIDHKQUCZNQY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  25.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(2-(Methylamino)propyl)benzofuran 在 二乙胺 、 三乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 生成 (2R)-1-(1-benzofuran-2-yl)-N-methylpropan-2-amine
  参考文献：
  名称：

  2-ETHYLAMINE SUBSTITUTED BENZOFURAN AND BENZOTHIOPHENE COMPOSITIONS FOR MENTAL DISORDERS OR ENHANCEMENT

  摘要：

  Pharmaceutically active 2-ethylamine substituted benzofuran and benzothiophene compositions are provided for the treatment of mental disorders or for mental enhancement, including for entactogenic therapy. The present invention also includes 2-ethylamine substituted benzofuran and benzothiophene compounds, compositions, and methods for generally modulating central nervous system activity and treating central nervous system disorders.

  公开号：

  WO2024108179A2
• 作为产物：
  描述：

  2-溴-1-苯并呋喃 在 三正丁基甲氧基锡 、 sodium cyanoborohydride 、 palladium dichloride 作用下， 以 甲醇 、 甲苯 为溶剂， 生成 2-(2-(Methylamino)propyl)benzofuran
  参考文献：
  名称：

  2-ETHYLAMINE SUBSTITUTED BENZOFURAN AND BENZOTHIOPHENE COMPOSITIONS FOR MENTAL DISORDERS OR ENHANCEMENT

  摘要：

  Pharmaceutically active 2-ethylamine substituted benzofuran and benzothiophene compositions are provided for the treatment of mental disorders or for mental enhancement, including for entactogenic therapy. The present invention also includes 2-ethylamine substituted benzofuran and benzothiophene compounds, compositions, and methods for generally modulating central nervous system activity and treating central nervous system disorders.

  公开号：

  WO2024108179A2

文献信息

• 2-ETHYLAMINE SUBSTITUTED BENZOFURAN AND BENZOTHIOPHENE COMPOSITIONS FOR MENTAL DISORDERS OR ENHANCEMENT
  申请人：[en]TACTOGEN INC

  公开号：WO2024108179A2

  公开（公告）日：2024-05-23

  Pharmaceutically active 2-ethylamine substituted benzofuran and benzothiophene compositions are provided for the treatment of mental disorders or for mental enhancement, including for entactogenic therapy. The present invention also includes 2-ethylamine substituted benzofuran and benzothiophene compounds, compositions, and methods for generally modulating central nervous system activity and treating central nervous system disorders.