9,10-二去氢-6-甲基麦角灵-8b-羧酸吗啉基酯 | 4314-63-0

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 麦角林及其衍生物
• 中文名称: 9,10-二去氢-6-甲基麦角灵-8b-羧酸吗啉基酯
• 英文名称: 4-(6-methyl-9,10-didehydro-ergoline-8-carbonyl)-morpholine
• 英文别名: 4-(6-Methyl-9,10-didehydro-ergolin-8β-carbonyl)-morpholin；Lysergic acid morpholide；[(6aR,9R)-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinolin-9-yl]-morpholin-4-ylmethanone
• CAS: 4314-63-0
• 化学式: C₂₀H₂₃N₃O₂
• 分子量: 337.422
• InChiKey: OTQWCDNEJVKXKG-RDTXWAMCSA-N

物化性质

• 沸点：
  473.72°C (rough estimate)
• 密度：
  1.1676 (rough estimate)
• 熔点：
  116 °C(Solv: benzene (71-43-2))

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  25
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  48.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  吗啉 、 lysergic acid-azide; hydrochloride 生成 4-(6-methyl-9,10-didehydro-ergoline-8α-carbonyl)-morpholine 、 9,10-二去氢-6-甲基麦角灵-8b-羧酸吗啉基酯
  参考文献：
  名称：

  立体异构麦角麦角酸和二氢麦角麦角酸的酰胺。38.关于麦角生物碱的交流

  摘要：

  描述了麦芽糖酸，异麦角酸，二氢麦角酸（I）和二氢异麦角酸（I）与伯胺和仲胺的大量酰胺酰胺类衍生物的存在和性质。

  DOI：

  10.1002/hlca.19550380207

文献信息

• COMPOSITIONS COMPRISING A PSILOCYBIN DERIVATIVE AND A CANNABINOID
  申请人：CaaMTech, LLC

  公开号：US20190142851A1

  公开（公告）日：2019-05-16

  This disclosure pertains to new compositions and methods comprising a psilocybin derivative. In one embodiment, the compositions disclosed herein are used for a method of regulating a neurotransmitter receptor, e.g., a serotonin receptor. In one embodiment, the compositions disclosed herein comprise purified compounds, e.g., a purified psilocybin derivative, a purified cannabinoid, or purified terpene.
• COMPOSITIONS COMPRISING A SEROTONERGIC TRYPTAMINE COMPOUND
  申请人：CAAMTECH, INC.

  公开号：US20210346346A1

  公开（公告）日：2021-11-11

  Disclosed herein are compositions comprising a serotonergic tryptamine compound, combinations thereof, and methods of using them for treating and preventing a variety of human conditions. In one embodiment, disclosed herein are new compositions and methods which comprise a therapeutically effective amount of a first purified psilocybin derivative and a therapeutically effective amount of a second compound. The second compound is selected from the group consisting of a second purified psilocybin derivative, a purified terpene, a serotonergic drug, an adrenergic drug, a dopaminergic drug, a purified erinacine, and a purified hericenone.
• [EN] COMPOSITIONS AND METHODS FOR TREATING MIGRAINE<br/>[FR] COMPOSITIONS ET MÉTHODES DE TRAITEMENT DE LA MIGRAINE
  申请人：[en]WESANA HEALTH INC.

  公开号：WO2022115798A2

  公开（公告）日：2022-06-02

  As described below, the present disclosure features compositions containing a cannabidiol (CBD) and/or psilocybin, optionally in combination with a mushroom blend. The present disclosure also features methods for treating or preventing migraine, or symptoms thereof, with a cannabidiol and/or psilocybin, optionally in combination with a mushroom blend. The present disclosure also features compositions and methods of using psilocybin in combination with a neurotransmitter activity modulator for the treatment of neurological conditions (e.g., migraine), or symptoms thereof (e.g., anxiety or depression).
• [EN] NOVEL ERGOLINES AND METHODS OF TREATING MOOD DISORDERS<br/>[FR] NOUVELLES ERGOLINES ET PROCÉDÉS DE TRAITEMENT DE TROUBLES DE L'HUMEUR
  申请人：[en]GILGAMESH PHARMACEUTICALS, INC.

  公开号：WO2022226408A1

  公开（公告）日：2022-10-27

  The present disclosure provides ergoline compounds and their use in treating mood disorders. Pharmaceutical compositions and methods of making various ergoline compounds are provided.
• Amide der stereoisomeren Lysergsäuren und Dihydro-lysergsäuren. 38. Mitteilung über Mutterkornalkaloide
  作者：A. Stoll、A. Hofmann

  DOI：10.1002/hlca.19550380207

  日期：——

  Es werden Darstellung und Eigenschaften einer grössern Anzahl säureamidartiger Derivate der Lysergsäure, Isolysergsäure, Dihydro-lysergsäure(I) und Dihydro-isolysergsäure(I) mit primären und sekundären Aminen beschrieben.

  描述了麦芽糖酸，异麦角酸，二氢麦角酸（I）和二氢异麦角酸（I）与伯胺和仲胺的大量酰胺酰胺类衍生物的存在和性质。