9,10-二去氢-N,N,6-三甲基麦角灵-8b-甲酰胺 | 4238-84-0

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 麦角林及其衍生物
• 中文名称: 9,10-二去氢-N,N,6-三甲基麦角灵-8b-甲酰胺
• 英文名称: N,N-Dimethyllysergamide
• 英文别名: DAM-57；Lysergsaeure-N,N-dimethylamid；6-methyl-9,10-didehydro-ergoline-8-carboxylic acid dimethylamide；(+)-Lysergsaeure-dimethylamid；d-Lysergic acid dimethylamide；(6aR,9R)-N,N,7-trimethyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide
• CAS: 4238-84-0
• 化学式: C₁₈H₂₁N₃O
• 分子量: 295.384
• InChiKey: FWHSERNVTGTIJE-MLGOLLRUSA-N

物化性质

• 沸点：
  437.06°C (rough estimate)
• 密度：
  1.1190 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  39.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  lysergic acid-azide; hydrochloride 、 二甲胺 生成 Iso-lysergsaeure-N,N-dimethylamid 、 9,10-二去氢-N,N,6-三甲基麦角灵-8b-甲酰胺
  参考文献：
  名称：

  立体异构麦角麦角酸和二氢麦角麦角酸的酰胺。38.关于麦角生物碱的交流

  摘要：

  描述了麦芽糖酸，异麦角酸，二氢麦角酸（I）和二氢异麦角酸（I）与伯胺和仲胺的大量酰胺酰胺类衍生物的存在和性质。

  DOI：

  10.1002/hlca.19550380207

文献信息

• INSTRUMENT FOR ALLEVIATING ADDICTIVE DRUG CRAVING, METHOD FOR USING SAME AND METHOD FOR TREATING ADDICTIVE DRUG DEPENDENCE
  申请人：Hirai, Shinji

  公开号：EP2371340A1

  公开（公告）日：2011-10-05

  Provided is an instrument for alleviating addictive drug craving which can be safely administered to an addictive drug-dependent patient by a definite method in practice without causing any undesirable effects on therapy and terminate a series of behaviors through the administration so as to achieve an excellent effect on the therapy for alleviating addictive drug craving. An instrument for alleviating addictive drug craving (11) which comprises a pseudo injection agent (31) enclosed in a pseudo container (21). To the outer face of the pseudo container (21), which is an ampule-shaped container being similar in appearance and structure to a container of an addictive drug (X), a pseudo injection agent label (41), which is almost the same in constitution to a product label of the container of the addictive drug (X) except having the term "PSEUDO" added hereto, is attached. The pseudo injection agent (31) is similar in appearance to an injection agent of the addictive drug (X) but free from the active ingredient of the addictive drug (X).

  本发明提供了一种用于缓解成瘾性药物渴求的仪器，在实践中可通过确定的方法对成瘾性药物依赖患者安全给药，而不会对治疗造成任何不良影响，并通过给药终止一系列行为，从而达到缓解成瘾性药物渴求治疗的良好效果。一种缓解药物成瘾渴求的仪器（11），它包括一个封闭在伪容器（21）中的伪注射剂（31）。伪容器 (21) 是一个在外观和结构上与成瘾药物容器 (X) 相似的安瓿形容器，在伪容器 (21) 的外表面附有一个伪注射剂标签 (41)，该标签的构成与成瘾药物容器 (X) 的产品标签几乎相同，只是在标签上添加了 "PSEUDO "一词。伪注射剂（31）的外观与成瘾药物（X）的注射剂相似，但不含成瘾药物（X）的活性成分。
• COMPOSITIONS COMPRISING A PSILOCYBIN DERIVATIVE AND A CANNABINOID
  申请人：CaaMTech, LLC

  公开号：US20190142851A1

  公开（公告）日：2019-05-16

  This disclosure pertains to new compositions and methods comprising a psilocybin derivative. In one embodiment, the compositions disclosed herein are used for a method of regulating a neurotransmitter receptor, e.g., a serotonin receptor. In one embodiment, the compositions disclosed herein comprise purified compounds, e.g., a purified psilocybin derivative, a purified cannabinoid, or purified terpene.
• COMPOSITIONS COMPRISING A SEROTONERGIC TRYPTAMINE COMPOUND
  申请人：CAAMTECH, INC.

  公开号：US20210346346A1

  公开（公告）日：2021-11-11

  Disclosed herein are compositions comprising a serotonergic tryptamine compound, combinations thereof, and methods of using them for treating and preventing a variety of human conditions. In one embodiment, disclosed herein are new compositions and methods which comprise a therapeutically effective amount of a first purified psilocybin derivative and a therapeutically effective amount of a second compound. The second compound is selected from the group consisting of a second purified psilocybin derivative, a purified terpene, a serotonergic drug, an adrenergic drug, a dopaminergic drug, a purified erinacine, and a purified hericenone.
• [EN] INSECTICIDAL DESPYRROLE ANALOGS OF LISURIDE AND LYSERGAMIDES<br/>[FR] DESPYRROLES INSECTICIDES ANALOGUES DE LISURIDE ET DE LYSERGAMIDES
  申请人：BAYER CROPSCIENCE AG

  公开号：WO2007128409A1

  公开（公告）日：2007-11-15

  [EN] Certain novel despyrrole analogs of lisuride and lysergamides have unexpected insecticidal activity. These compounds are represented by formula (I): where R and R² are fully described herein. The compounds being particularly useful in compositions comprising an insecticidally effective amount of at least one compound of formula (I), and an insecticidally compatible carrier are also disclosed; along with methods of controlling insects comprising applying said compositions to a locus where insects are present or are expected to be present.
  [FR] Certains nouveaux despyrroles analogues du lisuride et des présentent une activité insecticide inattendue. Ces composés sont représentés par la formule (I) dans laquelle: R et R2 sont décrits dans la description. Ces composés sont particulièrement utiles dans des compositions comprenant une quantité à effet insecticide d'au moins l'un des composés de formule (I). L'invention porte également sur un excipient adapté et sur une méthode d'éradication d'insectes consistant à appliquer une telle composition dans un endroit ou des insectes se trouvent eu sont censés se trouver.
• [EN] COMPOSITIONS AND METHODS FOR TREATING MIGRAINE<br/>[FR] COMPOSITIONS ET MÉTHODES DE TRAITEMENT DE LA MIGRAINE
  申请人：[en]WESANA HEALTH INC.

  公开号：WO2022115798A2

  公开（公告）日：2022-06-02

  As described below, the present disclosure features compositions containing a cannabidiol (CBD) and/or psilocybin, optionally in combination with a mushroom blend. The present disclosure also features methods for treating or preventing migraine, or symptoms thereof, with a cannabidiol and/or psilocybin, optionally in combination with a mushroom blend. The present disclosure also features compositions and methods of using psilocybin in combination with a neurotransmitter activity modulator for the treatment of neurological conditions (e.g., migraine), or symptoms thereof (e.g., anxiety or depression).