1,4-Bis-(dihexyl-phosphinoylmethyl)-piperazine | 815605-03-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1,4-Bis-(dihexyl-phosphinoylmethyl)-piperazine
• 英文别名: 1,4-Bis[(dihexylphosphoryl)methyl]piperazine；1,4-bis(dihexylphosphorylmethyl)piperazine
• CAS: 815605-03-9
• 化学式: C₃₀H₆₄N₂O₂P₂
• 分子量: 546.798
• InChiKey: UXDODKXUPWIRPZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.9
• 重原子数：
  36
• 可旋转键数：
  24
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  40.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  哌嗪 、 聚合甲醛 、 di-n-hexylphosphine oxide 在 对甲苯磺酸 作用下， 以 苯 为溶剂， 反应 1.5h， 生成 1,4-Bis-(dihexyl-phosphinoylmethyl)-piperazine
  参考文献：
  名称：

  Synthesis and Acid-Base Properties of  -Aminophosphoryl Compounds

  摘要：

  alpha-Aminophosphoryl compounds of the phosphonate, phosphine oxide, and alpha,omega-bis(phosphine oxide) series and some of their thiophosphoryl analogs were synthesized. Potentiometric measurements of the pK(a) of the conjugate acids revealed an insignificant effect of variation of substituents on the phosphorus, nitrogen, and alpha-carbon atoms on the basicity of the phosphorylated amines. The latter are weak bases. Organophosphorus groups decrease the basicity of the amines by almost 5 pK(a) units. The role of the hydrophobic effect and intramolecular H-bonding in the obtained substances was discussed.

  DOI：

  10.1023/b:rugc.0000042422.61124.b3

文献信息

• Synthesis and Acid-Base Properties of  -Aminophosphoryl Compounds
  作者：S. V. Zakharov、G. Kh. Nuriazdanova、A. R. Garifzyanov、V. I. Galkin、R. A. Cherkasov

  DOI：10.1023/b:rugc.0000042422.61124.b3

  日期：2004.6

  alpha-Aminophosphoryl compounds of the phosphonate, phosphine oxide, and alpha,omega-bis(phosphine oxide) series and some of their thiophosphoryl analogs were synthesized. Potentiometric measurements of the pK(a) of the conjugate acids revealed an insignificant effect of variation of substituents on the phosphorus, nitrogen, and alpha-carbon atoms on the basicity of the phosphorylated amines. The latter are weak bases. Organophosphorus groups decrease the basicity of the amines by almost 5 pK(a) units. The role of the hydrophobic effect and intramolecular H-bonding in the obtained substances was discussed.