13-iso-4-methyldecarboxyhaumanamide | 1224111-80-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 13-iso-4-methyldecarboxyhaumanamide
• 英文别名: (3aS,3bR,5aS,9aS,9bR)-3b,6,6,9a-tetramethyl-2-(2-phenylethyl)-1,3a,4,5,5a,7,8,9,9b,10-decahydronaphtho[1,2-g]isoindol-3-one
• CAS: 1224111-80-1
• 化学式: C₂₈H₃₉NO
• 分子量: 405.624
• InChiKey: NGRVMDXHBBUENZ-KZEXJIRGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  30
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  13-iso-4-methyldecarboxyhaumanamide 在 甲醇 、 potassium hydroxide 作用下， 反应 3.0h， 以92%的产率得到4-methyldecarboxyhaumanamide
  参考文献：
  名称：

  Expeditious synthesis of nitrogenated spongianes: 4-methyldecarboxyspongolactams

  摘要：

  Herein, the synthesis of 4-methyldecarboxyhaumanamide (9) and 4-methyldecarboxyspongolactams A (11) and C (13) is presented. (-)-Sclareol is the starting material and the chloroderivative 7 is the common intermediate. Moreover, this synthesis represents a new strategy for the preparation of pyrrolinones. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.01.091
• 作为产物：
  描述：

  methyl 16-chloro-isoanticopal-12-en-15-oate 、 2-苯乙胺 在 sodium cyanide 作用下， 反应 24.0h， 以81%的产率得到13-iso-4-methyldecarboxyhaumanamide
  参考文献：
  名称：

  Expeditious synthesis of nitrogenated spongianes: 4-methyldecarboxyspongolactams

  摘要：

  Herein, the synthesis of 4-methyldecarboxyhaumanamide (9) and 4-methyldecarboxyspongolactams A (11) and C (13) is presented. (-)-Sclareol is the starting material and the chloroderivative 7 is the common intermediate. Moreover, this synthesis represents a new strategy for the preparation of pyrrolinones. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.01.091

文献信息

• Expeditious synthesis of nitrogenated spongianes: 4-methyldecarboxyspongolactams
  作者：P. Basabe、A. Blanco、O. Bodero、M. Martín、I.S. Marcos、D. Díez、F. Mollinedo、J.G. Urones

  DOI：10.1016/j.tet.2010.01.091

  日期：2010.3

  Herein, the synthesis of 4-methyldecarboxyhaumanamide (9) and 4-methyldecarboxyspongolactams A (11) and C (13) is presented. (-)-Sclareol is the starting material and the chloroderivative 7 is the common intermediate. Moreover, this synthesis represents a new strategy for the preparation of pyrrolinones. (C) 2010 Elsevier Ltd. All rights reserved.