(14-bromo-tetradecyloxy)-tert-butyl-dimethylsilane | 568561-96-6

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: (14-bromo-tetradecyloxy)-tert-butyl-dimethylsilane
• 英文别名: 14-bromo-1-(t-butyldimethylsiloxy)tetradecane；14-bromotetradecoxy-tert-butyl-dimethylsilane
• CAS: 568561-96-6
• 化学式: C₂₀H₄₃BrOSi
• 分子量: 407.55
• InChiKey: MSTGKPXUYRIIPC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.08
• 重原子数：
  23
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (14-bromo-tetradecyloxy)-tert-butyl-dimethylsilane 在 正丁基锂 、 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 生成 14-(2,5-dimethoxyphenylamino)tetradecan-1-ol
  参考文献：
  名称：

  Solid-phase synthesis of quinol fatty alcohols, design of N/O-substituted quinol fatty alcohols and comparative activities on axonal growth

  摘要：

  Following the promising activity of Q(2)FA15 on axonal growth, two new series of N/O-substituted QFAs were synthesized, based on a S(N)2-type reaction. O-alkylated QFA bearing 14 carbon atoms on the side chain (n = 14) shows a very potent activity on axonal growth though lowered when compared to Q(2)FA15. While O-alkylation allows good retention of the biological activity, N-alkylation abolishes it nonetheless. A solid-phase-supported synthesis of Q(2)FA15 allowing the conception of new hybrid compounds is also described. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.05.027
• 作为产物：
  描述：

  十四烷二酸 在 咪唑 、 lithium aluminium tetrahydride 、 氢溴酸 作用下， 以 二氯甲烷 、 环己烷 为溶剂， 反应 10.0h， 生成 (14-bromo-tetradecyloxy)-tert-butyl-dimethylsilane
  参考文献：
  名称：

  Solid-phase synthesis of quinol fatty alcohols, design of N/O-substituted quinol fatty alcohols and comparative activities on axonal growth

  摘要：

  Following the promising activity of Q(2)FA15 on axonal growth, two new series of N/O-substituted QFAs were synthesized, based on a S(N)2-type reaction. O-alkylated QFA bearing 14 carbon atoms on the side chain (n = 14) shows a very potent activity on axonal growth though lowered when compared to Q(2)FA15. While O-alkylation allows good retention of the biological activity, N-alkylation abolishes it nonetheless. A solid-phase-supported synthesis of Q(2)FA15 allowing the conception of new hybrid compounds is also described. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.05.027

文献信息

• [EN] PROCESS FOR PRODUCING CYCLOHEXENONE LONG-CHAIN ALCOHOLS<br/>[FR] PROCEDE PERMETTANT DE PRODUIRE DES ALCOOLS DE CYCLOHEXENONE A LONGUE CHAINE
  申请人：MEIJI DAIRIES CORP

  公开号：WO2004087630A1

  公开（公告）日：2004-10-14

  A process for producing cyclohexenone long-chain alcohol represented by the following formula (1): (wherein A represents a C10-C18 alkylene or alkenylene group, and each of R1, R2, and R3 individually represents hydrogen or methyl), comprising reacting a 3-alkoxy-2-cyclohexen-1-one derivative represented by the following formula (2): (wherein R1, R2, and R3 have the same meanings as above, and R4 represents a C1-C5 alkyl group) with a Grignard's reagent prepared by protecting the hydroxyl groups of C10-C18 ω-halogenoalcohol through silylation, and hydrolyzing the resultant reaction product. The process of the present invention for producing cyclohexenone long-chain alcohol requires a reduced number of reaction steps, can be performed with ease and with reduced production cost, and thus finds utility in the industry.

  通过保护C10-C18 ω-卤代醇的羟基，通过硅化反应制备格氏试剂，然后与以下公式（2）所代表的3-烷氧基-2-环己烯-1-酮衍生物发生反应（其中R1、R2和R3具有与上述相同的含义，R4代表C1-C5烷基），从而制备由以下公式（1）表示的环己烯酮长链醇的方法：（其中A表示C10-C18烷基或烯基，R1、R2和R3中的每一个单独表示氢或甲基），并水解生成的反应产物。本发明的制备环己烯酮长链醇的方法需要较少的反应步骤，易于操作，生产成本较低，因此在工业中具有实用性。
• Indole derivatives and drugs containing the same
  申请人：Luu Bang

  公开号：US20050261357A1

  公开（公告）日：2005-11-24

  An indole derivative represented by the following general formula (1): wherein at least one of R 1 , R 2 , R 3 , and R 4 represents an alkoxy group containing 1 to 20 carbon atoms, and other groups of the R 1 , R 2 , R 3 , and R 4 represent hydrogen, an alkyl group containing 1 to 6 carbon atoms, acetyl group, or hydroxyl group; and either one of X and Y represents —(CH 2 ) n OH wherein n is an integer of 0 to 30, and the other one of the X and Y represents hydrogen atom; or a salt thereof; and a drug and an agent for promoting differentiation of a stem cell containing such indole derivative or its salt as an effective component. The indole derivative (1) of the present invention has action of inducing differentiation of neural stem cell specifically into a neuron, and this indole derivative is useful as a prophylactic or therapeutic drug for brain dysfunction or neuropathy caused by loss or degeneration of the neuron.

  以下是一种由下述通式（1）表示的吲哚衍生物: 其中，R1、R2、R3和R4中至少有一个表示含有1到20个碳原子的烷氧基，而R1、R2、R3和R4的其他基团则表示氢、含有1到6个碳原子的烷基、乙酰基或羟基；X和Y中的一个表示—（CH2）nOH，其中n为0到30的整数，而X和Y的另一个表示氢原子；或其盐；以及包含这种吲哚衍生物或其盐作为有效成分的药物和促进干细胞分化的药剂。本发明的吲哚衍生物（1）具有特异性诱导神经干细胞分化为神经元的作用，因此这种吲哚衍生物可用作预防或治疗因神经元丧失或退化引起的脑功能障碍或神经病变的药物。
• EP1533299
  申请人：——

  公开号：——

  公开（公告）日：——