9-Fluoro-11,17-dihydroxypregn-4-ene-3,20-dione

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 9-Fluoro-11,17-dihydroxypregn-4-ene-3,20-dione
• 英文别名: 17-acetyl-9-fluoro-11,17-dihydroxy-10,13-dimethyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
• 化学式: C₂₁H₂₉FO₄
• 分子量: 364.4
• InChiKey: OFSXGKOMEGSTSE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  26
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• [EN] GLASS FORMULATIONS COMPRISING STEROID DIMERS AND USES THEREOF<br/>[FR] FORMULATIONS DE VERRE COMPRENANT DES DIMÈRES STÉROÏDIENS ET UTILISATIONS ASSOCIÉES
  申请人：INTERFACE BIOLOGICS INC

  公开号：WO2019148293A1

  公开（公告）日：2019-08-08

  Steroid dimers and articles formed from steroid dimers are disclosed. Said steroid dimers are represented by D1-L-D2 wherein D1 and D2 are steroid moieties and L is a covalent linker. The articles comprising the steroid dimers can be machined, molded, emulsion-processed, electrospun, electrosprayed, blow molded, fiber spun, wet spun, dry spun, melt spun, heat spun, gel spun, or extruded to form a fiber, fiber mesh, woven fabric, non-woven fabric, pellet, cylinder, microparticle, nanoparticle, or shaped article. Said articles are used as drug delivery devices (e.g. an implant) for the extended delivery of a steroid to a subject.
• [EN] SURFACE COATINGS AND IMPLANTABLE DEVICES COMPRISING DIMERIC STEROID PRODRUGS, AND USES THEREOF<br/>[FR] ENDUITS DE SURFACE, DISPOSITIFS IMPLANTABLES COMPRENANT DES PROMÉDICAMENTS STÉROÏDIENS DIMÈRES ET LEURS UTILISATIONS
  申请人：RIPPLE THERAPEUTICS CORP

  公开号：WO2021005417A1

  公开（公告）日：2021-01-14

  The disclosure features surface coatings formed from dimeric steroid prodrugs for the extended delivery of a drug from a surface, and for the treatment of a disease or condition. Also provided herein are drug depots formed from dimeric steroid prodrugs for the extended delivery of a drug for use in combination with implantable medical devices. Said dimeric steroid prodrugs are represented by the formula D1-L-D2, wherein D1 and D2 are independently a steroid radical and L is a linker covalently linking D1 to D2.
• [EN] ARTICLES COMPRISING STEROID DIMERS AND THEIR USE IN THE DELIVERY OF THERAPEUTIC AGENTS<br/>[FR] ARTICLES COMPRENANT DES DIMÈRES STÉROÏDES ET LEUR UTILISATION DANS L'ADMINISTRATION D'AGENTS THÉRAPEUTIQUES
  申请人：RIPPLE THERAPEUTICS CORP

  公开号：WO2021014217A1

  公开（公告）日：2021-01-28

  The present invention is directed towards articles comprising a steroid material comprising a steroid dimer and at least one therapeutic agent distributed throughout the steroid material and the use of such articles in sustained release delivery systems. Said article may be fibers, fiber meshes, woven fabrics, non-woven fabrics, films, pellets, cylinders, microparticles, nanoparticles, shaped articles or coatings on a substrate (such as an implant). Control of the release profile of the at least one therapeutic agent can be achieved via selection of the steroids within the steroid dimer, the linker conjugating the steroids within the dimer, the linkage groups between the steroids and the linker, the surface area of the article, the location of the at least one therapeutic agent within the article and the amount of the at least one therapeutic agent within the article.