5-[(3,5-dimethyl-4-hydroxyphenyl)methylene]-2-thioxo-4-thiazolidinone

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 5-[(3,5-dimethyl-4-hydroxyphenyl)methylene]-2-thioxo-4-thiazolidinone
• 英文别名: (5E)-5-[(4-hydroxy-3,5-dimethylphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
• 化学式: C₁₂H₁₁NO₂S₂
• 分子量: 265.357
• InChiKey: NPYSSQZXRXNSQT-WEVVVXLNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  107
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Arylmethylenyl derivatives of thiazolidnones, imidazolidinones and oxazolidinones useful as antiallergy agents and antiinflamatory agents
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP0343643A2

  公开（公告）日：1989-11-29

  The present invention is for selected novel compounds, as well as, pharmaceutical compositions and methods of use for known and the selected novel compounds both of the formula having activity useful for treating allergies and inflammation.

  本发明涉及所选的新型化合物，以及已知和所选的新型化合物的药物组合物和使用方法，这两种化合物的化学式均为 具有治疗过敏症和炎症的活性。
• Thiazolidinone derivatives as hypoglycemic agents and for treating Alzheimer's disease
  申请人：ELI LILLY AND COMPANY

  公开号：EP0587377A2

  公开（公告）日：1994-03-16

  Provided are methods for treating hyperglycemia and Alzheimer's disease utilizing certain rhodanine derivatives. Certain of the rhodanine derivatives utilized in the instant methods are novel and, accordingly, such compounds, process for preparing same and pharmaceutical formulations thereof, are also provided.

  本发明提供了利用某些罗丹宁衍生物治疗高血糖和阿尔茨海默病的方法。在本方法中使用的某些罗丹宁衍生物是新颖的，因此还提供了此类化合物、其制备工艺和药物制剂。
• Aryl-substituted rhodanines for treating multiple sclerosis
  申请人：ELI LILLY AND COMPANY

  公开号：EP0722729A2

  公开（公告）日：1996-07-24

  Provided is a method of treating multiple sclerosis employing certain aryl-substituted rhodanines:

  本文提供了一种利用某些芳基取代的罗丹宁治疗多发性硬化症的方法：
• Compounds useful as hypoglycemic agents and for treating Alzheimer's disease
  申请人：ELI LILLY AND COMPANY

  公开号：EP0915090A1

  公开（公告）日：1999-05-12

  Provided are methods for treating hyperglycemia and Alzheimer's disease utilizing certain rhodanine derivatives. Certain of the rhodanine derivatives utilized in the instant methods are novel and, accordingly, such compounds, process for preparing same and pharmaceutical formulations thereof, are also provided.

  本发明提供了利用某些罗丹宁衍生物治疗高血糖和阿尔茨海默病的方法。在本方法中使用的某些罗丹宁衍生物是新颖的，因此还提供了此类化合物、其制备工艺和药物制剂。
• SPLIT PHOTOACTIVE YELLOW PROTEIN COMPLEMENTATION SYSTEM AND USES THEREOF
  申请人：Paris Sciences et Lettres - Quartier Latin

  公开号：EP3719007A1

  公开（公告）日：2020-10-07

  The present invention relates to a complementation system comprising two fragments of photoactive yellow protein (PYP), or truncated fragments thereof, and its use with a fluorogenic hydroxybenzylidene rhodanine (HBR) analog for detecting interaction between biological molecules of interest, in particular between proteins of interest. The present invention especially relates to a complementation system comprising a first PYP fragment comprising an amino acid sequence having at least about 70% identity with the amino acid sequence as set forth in SEQ ID NO: 23, or a truncated fragment thereof comprising at least 89 consecutive amino acids from the C-terminal end of said amino acid sequence; and a second PYP fragment comprising an amino acid sequence having at least about 70% identity with the amino acid sequence as set forth in SEQ ID NO: 34, or a truncated fragment thereof comprising at least 8 consecutive amino acids of said amino acid sequence.

  本发明涉及一种由光活性黄蛋白（PYP）的两个片段或其截断片段组成的互补系统，及其与含氟羟基亚苄基罗丹宁（HBR）类似物一起用于检测相关生物分子之间的相互作用，特别是相关蛋白质之间的相互作用。 本发明尤其涉及一种互补系统，该系统包含第一个PYP片段，其氨基酸序列与SEQ ID NO：23 所述氨基酸序列至少具有约 70% 的同一性的氨基酸序列，或其截短片段，该片段包含所述氨基酸序列 C 端起至少 89 个连续氨基酸；以及第二PYP 片段，该片段包含与 SEQ ID NO: 34 所述氨基酸序列至少具有约 70% 的同一性的氨基酸序列，或其截短片段，该片段包含所述氨基酸序列的至少 8 个连续氨基酸。