2-[2-(3-Methyl-1-adamantyl)ethyl]guanidine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-[2-(3-Methyl-1-adamantyl)ethyl]guanidine
• 化学式: C₁₄H₂₅N₃
• 分子量: 235.37
• InChiKey: MXDPBLBPNSFKMX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  64.4
• 氢给体数：
  2
• 氢受体数：
  1

文献信息

• Novel adamantane derivatives with neuroprotective, antidepressant and anti-ischaemic activities,and process for preparing them
  申请人：Makovec Francesco

  公开号：US20050049312A1

  公开（公告）日：2005-03-03

  The invention describes compounds represented by the general formula (I) given below: in which: n is an integer between 1 and 4; R 1 and R 2 are chosen independently from hydrogen and a methyl group; R 3 is chosen independently from a linear, branched or cyclic alkyl group containing from 1 to 3 carbon atoms (R 3a ) and a simple amino group (R 3b ) or an amino group substituted with a nitro group (R 3c ) The compounds are useful for treating central nervous system diseases or peripheral neuropathies.

  该发明描述了由以下通式(I)表示的化合物：其中：n是介于1和4之间的整数；R1和R2是独立选择的氢和甲基基团；R3是独立选择的线性、支链或环烷基基团，包含1至3个碳原子（R3a）和一个简单的氨基基团（R3b）或一个被硝基基团取代的氨基基团（R3c）。这些化合物可用于治疗中枢神经系统疾病或周围神经病变。
• Novel adamantane derivatives with neuroprotective, antidepressant and anti-ischaemic activities, and process for preparing them
  申请人：ROTTA RESEARCH LABORATORIUM S.P.A.

  公开号：EP1512679A1

  公开（公告）日：2005-03-09

  The invention describes compounds represented by the general formula (I) given below: in which: n is an integer between 1 and 4; R1 and R2 are chosen independently from hydrogen and a methyl group; R3 is chosen independently from a linear, branched or cyclic alkyl group containing from 1 to 3 carbon atoms (R3a) and a simple amino group (R3b) or an amino group substituted with a nitro group (R3c). The compounds are useful for treating central nervous system diseases or peripheral neuropathies.

  本发明描述了如下通式(I)所代表的化合物： 其中 n 是介于 1 和 4 之间的整数； R1 和 R2 分别选自氢和甲基； R3 独立地选自含有 1 至 3 个碳原子的直链、支链或环状烷基（R3a）和单氨基（R3b）或被硝基取代的氨基（R3c）。这些化合物可用于治疗中枢神经系统疾病或周围神经病。
• US7145037B2
  申请人：——

  公开号：US7145037B2

  公开（公告）日：2006-12-05