Triphosphoric acid, P-((5-(4-amino-7H-pyrrolo(2,3-d)pyrimidin-7-yl)tetrahydro-2-furanyl)methyl) ester, (2S-cis)- | 117560-92-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并嘧啶类
• 英文名称: Triphosphoric acid, P-((5-(4-amino-7H-pyrrolo(2,3-d)pyrimidin-7-yl)tetrahydro-2-furanyl)methyl) ester, (2S-cis)-
• 英文别名: [[(2S,5R)-5-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
• CAS: 117560-92-6
• 化学式: C₁₁H₁₇N₄O₁₁P₃
• 分子量: 474.19
• InChiKey: OJEBBDUVAVGFLX-IONNQARKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.2
• 重原子数：
  29
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  226
• 氢给体数：
  5
• 氢受体数：
  14

文献信息

• NUCLEOTIDE ANALOGUES
  申请人：Intelligent Biosystems, Inc.

  公开号：US20170130051A1

  公开（公告）日：2017-05-11

  The present invention provides methods, compositions, mixtures and kits utilizing deoxynucleoside triphosphates comprising a 3′-O position capped by a group comprising methylenedisulfide as a cleavable protecting group and a detectable label reversibly connected to the nucleobase of said deoxynucleoside. Such compounds provide new possibilities for future sequencing technologies, including but not limited to Sequencing by Synthesis.

  本发明提供了利用包含由甲亚砜二硫醚作为可裂解保护基团的3'-O位置封端的脱氧核苷三磷酸的方法、组合物、混合物和试剂盒，以及可逆地连接到所述脱氧核苷的核碱基的可检测标签。这些化合物为未来的测序技术提供了新的可能性，包括但不限于合成测序。
• DNA sequencing reaction additive
  申请人：Qiagen Sciences, LLC

  公开号：US10844430B2

  公开（公告）日：2020-11-24

  The present invention provides methods, compositions, mixtures and kits utilizing 5-Chloro-2-methyl-4-isothiazolin-3-one in sequencing reactions, and in particular, sequencing reactions where deoxynucleoside triphosphates comprising a 3′-O position capped by a disulfide-based 3′-terminator group are used. In one embodiment, the deoxynucleoside triphosphates comprise a 3′-O position capped by a group comprising methylenedisulfide as a cleavable protecting group and a detectable label reversibly connected to the nucleobase of said deoxynucleoside. In addition, thiol-containing compounds and scavengers of thio-containing compounds are described. Such compounds provide new possibilities for future sequencing technologies, including but not limited to Sequencing by Synthesis.

  本发明提供了利用5-氯-2-甲基-4-异噻唑啉-3-酮在测序反应中的方法、组合物、混合物和试剂盒，特别是在使用由二硫化物基团封端的3′-O位置的脱氧核苷三磷酸的测序反应中。在一种实施例中，脱氧核苷三磷酸包括由亚甲基二硫醚作为可切割保护基团的3′-O位置，并且可检测标签可逆地连接到所述脱氧核苷的核碱基。此外，描述了含硫醇化合物和硫醇化合物的清除剂。这些化合物为未来的测序技术提供了新的可能性，包括但不限于合成测序。
• Nucleotide analogues
  申请人：QIAGEN WALTHAM, INC.

  公开号：US10301346B2

  公开（公告）日：2019-05-28

  The present invention provides methods, compositions, mixtures and kits utilizing deoxynucleoside triphosphates comprising a 3′-O position capped by a group comprising methylenedisulfide as a cleavable protecting group and a detectable label reversibly connected to the nucleobase of said deoxynucleoside. Such compounds provide new possibilities for future sequencing technologies, including but not limited to Sequencing by Synthesis.

  本发明提供了利用脱氧核苷三磷酸酯的方法、组合物、混合物和试剂盒，该脱氧核苷三磷酸酯包含一个 3′-O 位点，该位点被一个包含亚甲基二硫化物的基团封盖，该基团是一个可裂解的保护基团，以及一个与所述脱氧核苷的核碱基可逆连接的可检测标签。这种化合物为未来的测序技术提供了新的可能性，包括但不限于合成测序技术。
• Methods of using nucleotide analogues
  申请人：Intelligent BioSystems, Inc.

  公开号：US10273539B2

  公开（公告）日：2019-04-30

  The present invention provides methods, compositions, mixtures and kits utilizing deoxynucleoside triphosphates comprising a 3′-O position capped by a group comprising methylenedisulfide as a cleavable protecting group and a detectable label reversibly connected to the nucleobase of said deoxynucleoside. Such compounds provide new possibilities for future sequencing technologies, including but not limited to Sequencing by Synthesis.

  本发明提供了利用脱氧核苷三磷酸酯的方法、组合物、混合物和试剂盒，该脱氧核苷三磷酸酯包含一个 3′-O 位点，该位点被一个包含亚甲基二硫化物的基团封盖，该基团是一个可裂解的保护基团，以及一个与所述脱氧核苷的核碱基可逆连接的可检测标签。这种化合物为未来的测序技术提供了新的可能性，包括但不限于合成测序技术。
• METHODS OF USING NUCLEOTIDE ANALOGUES
  申请人：Intelligent BioSystems, Inc.

  公开号：US20170137878A1

  公开（公告）日：2017-05-18

  The present invention provides methods, compositions, mixtures and kits utilizing deoxynucleoside triphosphates comprising a 3′-O position capped by a group comprising methylenedisulfide as a cleavable protecting group and a detectable label reversibly connected to the nucleobase of said deoxynucleoside. Such compounds provide new possibilities for future sequencing technologies, including but not limited to Sequencing by Synthesis.