2-Amino-1-hydroxyquinazolin-4-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-Amino-1-hydroxyquinazolin-4-one
• 化学式: C₈H₇N₃O₂
• 分子量: 177.16
• InChiKey: DIOZMLIUHXTURD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  78.9
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Therapeutic compounds for the treatment of asthma and allergy, and methods of use thereof
  申请人：——

  公开号：US20020082268A1

  公开（公告）日：2002-06-27

  The present invention relates to compounds capable of inhibiting leukotriene activity and histamine activity, and their use in treating asthma and allergic conditions such as hay fever, dermatitus, and urticaria. Inhibition of both pathways permits more effective treatment of conditions with fewer side effects than can be achieved using most available antihistamines alone.

  本发明涉及一种能够抑制白三烯活性和组胺活性的化合物，以及它们在治疗哮喘和过敏症状，如花粉热、皮炎和荨麻疹方面的应用。抑制两个途径可以更有效地治疗病症，而且副作用比大多数现有的抗组胺药物单独使用时更少。
• [EN] THERAPEUTIC COMPOUNDS FOR THE TREATMENT OF ASTHMA AND ALLERGY, AND METHODS OF USE THEREOF<br/>[FR] COMPOSES THERAPEUTIQUES PERMETTANT DE TRAITER L'ASTHME ET L'ALLERGIE ET LEURS METHODES D'UTILISATION
  申请人：SEPRACOR INC

  公开号：WO2001070737A2

  公开（公告）日：2001-09-27

  The present invention relates to compounds capable of inhibiting leukotriene activity and histamine activity, and their use in treating asthma and allergic conditions such as hay fever, dermatitus, and urticaria. Inhibition of both pathways permits more effective treatment of conditions with fewer side effects than can be achieved using most available antihistamines alone.