Isopropoxyphene | 701900-96-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: Isopropoxyphene
• 英文别名: [(2S,3S)-4-(dimethylamino)-3-methyl-1,2-diphenylbutan-2-yl] propanoate
• CAS: 701900-96-1
• 化学式: C₂₂H₂₉NO₂
• 分子量: 339.5
• InChiKey: XLMALTXPSGQGBX-AVRDEDQJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  25
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• [EN] SOLID ORAL PHARMACEUTICAL COMPOSITIONS COMPRISING FIXED DOSE COMBINATION OF ACETAMINOPHEN, DICYCLOMINE AND DEXTROPROPOXYPHENE OR SALTS THEREOF<br/>[FR] COMPOSITIONS PHARMACEUTIQUES ORALES SOLIDES COMPRENANT UNE ASSOCIATION À DOSE FIXE D'ACÉTAMINOPHÈNE, DE DICYCLOMINE ET DE DEXTROPROPOXYPHÈNE OU LEURS SELS
  申请人：WOCKHARDT LTD

  公开号：WO2014203140A1

  公开（公告）日：2014-12-24

  The present invention relates to solid oral pharmaceutical compositions comprising fixed dose combination of acetaminophen, dicyclomine and dextropropoxyphene or salts thereof. In particular, the present invention relates to solid oral pharmaceutical compositions comprising fixed dose combination of acetaminophen, dicyclomine and dextropropoxyphene or salts thereof, one or more alkalizers, and other pharmaceutically acceptable excipients. The compositions of the present invention exhibit improved/faster dissolution profile of one or more active ingredients. The invention further relates to process of preparing said pharmaceutical compositions and their use as antispasmodic.