7H-Pyrrolo(3,2-f)quinazoline-1,3-diamine, 7-((4-aminophenyl)methyl)- | 750522-61-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 7H-Pyrrolo(3,2-f)quinazoline-1,3-diamine, 7-((4-aminophenyl)methyl)-
• 英文别名: 7-[(4-aminophenyl)methyl]pyrrolo[3,2-f]quinazoline-1,3-diamine
• CAS: 750522-61-3
• 化学式: C₁₇H₁₆N₆
• 分子量: 304.3
• InChiKey: LNEWNMFMWDBAKM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  109
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• MOLECULES WITH POTENT DHFR BINDING AFFINITY AND ANTIBACTERIAL ACTIVITY
  申请人：Georgia Tech Research Corporation

  公开号：US20140329840A1

  公开（公告）日：2014-11-06

  7-(substituted) derivatives of 7H-pyrrolo[3,2-f]-quinazoline-1,3-diamines, derivative thereof, and methods of using them are provided. The pharmaceutical formulations prepared from the compounds can be used to treat a variety of conditions, which include, but are not limited to bacterial and fungal infections. The compounds can also be used as a sterilizing or disinfecting agent.
• SETBP1 INHIBITORS FOR THE TREATMENT OF MYELOID NEOPLASMS AND SOLID TUMORS
  申请人：The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.

  公开号：US20210205306A1

  公开（公告）日：2021-07-08

  Chemical compounds for the treatment of myeloid neoplasms and solid tumors are described, where the compounds were identified through a screening process assessing the binding affinity of the compounds to a synthesized fragment of Setbp1 protein.
• US9920058B2
  申请人：——

  公开号：US9920058B2

  公开（公告）日：2018-03-20
• [EN] METTL16 INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS DE METTL 16 ET LEURS UTILISATIONS
  申请人：HOPE CITY

  公开号：WO2021035045A1

  公开（公告）日：2021-02-25

  The disclosure provides, inter alia, METTL16 inhibitors and methods of treating cancers that overexpress METTL16.