3-acetyl-2-isopropyl-4-phenyl-4H-chromene | 1632130-91-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 新黄酮类化合物
• 英文名称: 3-acetyl-2-isopropyl-4-phenyl-4H-chromene
• 英文别名: 1-(4-phenyl-2-propan-2-yl-4H-chromen-3-yl)ethanone
• CAS: 1632130-91-6
• 化学式: C₂₀H₂₀O₂
• 分子量: 292.378
• InChiKey: YYRLBEGCKBARFP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-(hydroxy(phenyl)methyl)phenol 、 异丁酰基丙酮 在 sodium bisulfate supported on silica gel 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 5.0h， 以47%的产率得到2-methyl-3-(2-methylpropionyl)-4-phenyl-4H-chromene
  参考文献：
  名称：

  One-Pot Synthesis of 4H-Chromenes by Tandem Benzylation and Cyclization in the Presence of Sodium Bisulfate on Silica Gel

  摘要：

  A simple and efficient method has been developed for the synthesis of 4H-chromenes from o-hydroxybenzylic alcohols and dicarbonyl compounds containing active methylene groups by using silica gel supported sodium bisulfate. Various dicarbonyl compounds such as diketones, keto esters, and keto amides can be used in the synthesis of the 4H-chromenes.

  DOI：

  10.1055/s-0033-1339026

文献信息

• One-Pot Synthesis of 4H-Chromenes by Tandem Benzylation and Cyclization in the Presence of Sodium Bisulfate on Silica Gel
  作者：Tadashi Aoyama、Takumi Yamamoto、Saki Miyota、Mamiko Hayakawa、Toshio Takido、Mitsuo Kodomari

  DOI：10.1055/s-0033-1339026

  日期：——

  A simple and efficient method has been developed for the synthesis of 4H-chromenes from o-hydroxybenzylic alcohols and dicarbonyl compounds containing active methylene groups by using silica gel supported sodium bisulfate. Various dicarbonyl compounds such as diketones, keto esters, and keto amides can be used in the synthesis of the 4H-chromenes.