2-methoxy-7-methyl-9H-xanthen-9-one | 57855-40-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 2-methoxy-7-methyl-9H-xanthen-9-one
• 英文别名: 3-methoxy-6-methyl-9H-xanthen-9-one；2-methoxy-7-methyl-xanthen-9-one；2-Methoxy-7-methyl-xanthen-9-on；2-Methoxy-7-methylxanthen-9-one；2-methoxy-7-methylxanthen-9-one
• CAS: 57855-40-0
• 化学式: C₁₅H₁₂O₃
• 分子量: 240.258
• InChiKey: WEKXQCCZZKVTJK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  9-hydroxy-2-methoxy-7-methyl-xanthene-9-carboxylic acid methyl ester 在 氢氧化钾 作用下， 生成 2-methoxy-7-methyl-9H-xanthen-9-one
  参考文献：
  名称：

  Kimoto, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1955, vol. 75, p. 509

  摘要：

  DOI：

文献信息

• Palladium-Catalyzed Oxidative Double CH Functionalization/Carbonylation for the Synthesis of Xanthones
  作者：Hua Zhang、Renyi Shi、Pei Gan、Chao Liu、Anxing Ding、Qiuyi Wang、Aiwen Lei

  DOI：10.1002/anie.201201050

  日期：2012.5.21

  Two at once: Xanthones with different functional groups were obtained with CO (balloon) in the presence of a simple catalytic system that consists of Pd(OAc)2, K2S2O8, and trifluoroacetic acid (see scheme). Preliminary mechanism studies reveal that the second CH functionalization might be the rate‐determining step.

  一次两个：在简单的催化体系（由Pd（OAc）2，K 2 S 2 O 8和三氟乙酸组成）的存在下，用CO（气球）获得具有不同官能团的氧杂蒽。初步的机理研究表明，第二个CH功能化可能是决定速率的步骤。
• New Methodology for the Synthesis of Xanthones
  申请人：Wang Qian

  公开号：US20140107354A1

  公开（公告）日：2014-04-17

  Methods are provided for forming a xanthone derivative via reacting a 2-substituted benzaldehyde with a phenol derivative to form the xanthone derivative.

  提供了一种方法，通过将2-取代苯甲醛与酚衍生物反应来形成黄酮衍生物。
• Synthesis of xanthones through the palladium-catalyzed carbonylation/C–H activation sequence
  作者：Yingmeng Xu、Jing Zhou、Congcong Zhang、Ke Chen、Tao Zhang、Zhenting Du

  DOI：10.1016/j.tetlet.2014.09.119

  日期：2014.11

  A series of xanthones with the dibenzo-γ-pyrone framework were synthesized through the palladium-catalyzed carbonylation/C–H activation sequence from the ortho diazonium salts of diaryl ethers in moderate to excellent yields. After screening the reaction condition, the optimal condition was 5 mol % tetrakis (triphenylphosphine) palladium (0) as the catalyst, potassium carbonate as the base, and toluene

  一系列与二苯并-γ吡喃酮框架呫通过钯催化的羰基/ C-H活化从序列合成邻二芳基醚类的重氮盐在中度至良好的产率。筛选反应条件后，最佳条件是在一氧化碳气氛下，在催化量的四丁基溴化铵存在下，以5 mol％四（三苯基膦）钯（0）​​为催化剂，碳酸钾为碱，甲苯为溶剂。 。
• Synthesis of Xanthones by Palladium-Catalyzed Tandem Carbonylation/C-H Activation via 2-Iodo Diaryl Ethers
  作者：Rui-Yue Ma、Ya-Fang Chen、Jun-Ru Wang、Zhen-Ting Du

  DOI：10.1002/jccs.201700125

  日期：2018.1

  The ring closure of 2‐iodo diaryl ether in the presence of a palladium catalyst to xanthone under carbon monoxide atmosphere is studied. A series of xanthones could be successfully obtained through this protocol, with Pd(OAc)2 as the catalyst, P(Cy)3 as ligand, PivONa.H2O as base, and PivOH and tetrabutylamonium bromide as additives in DMSO, in moderate to good yields.

  研究了一氧化碳气氛下钯催化剂存在下presence吨酮对2-碘二芳基醚的闭环作用。通过该方案可以成功获得一系列的氧杂蒽，以Pd（OAc）2为催化剂，P（Cy）3为配体，PivONa 。在DMSO中以H 2 O为碱，以PivOH和四丁基溴化铵为添加剂，收率中等至良好。
• Kimoto; Sakai; Okhuma, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1949, vol. 69, p. 405,406
  作者：Kimoto、Sakai、Okhuma

  DOI：——

  日期：——