2-Hydroxy-toluol-sulfonsaeure-(α) | 79427-87-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2-Hydroxy-toluol-sulfonsaeure-(α)
• 英文别名: o-Hydroxy-α-toluolsulfonsaeure；(2-Hydroxyphenyl)methanesulfonic acid
• CAS: 79427-87-5
• 化学式: C₇H₈O₄S
• 分子量: 188.204
• InChiKey: DHKIVCMLYUCALN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  83
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-Hydroxy-toluol-sulfonsaeure-(α) 在 五氯化磷 作用下， 生成 3H-苯并[d]氧硫杂环戊烷2,2-二氧化物
  参考文献：
  名称：

  Marckwald; Frahne, Chemische Berichte, 1898, vol. 31, p. 1861

  摘要：

  DOI：
• 作为产物：
  描述：

  水杨醇 在 水 、 sodium hydrogensulfite 作用下， 生成 2-Hydroxy-toluol-sulfonsaeure-(α)
  参考文献：
  名称：

  273.邻羟基苄基磺酸的衍生物

  摘要：

  DOI：

  10.1039/jr9370001348

文献信息

• An orally administrable drug form comprising a beta-lactam antibiotic and an adjuvant
  申请人：INTERx RESEARCH CORPORATION

  公开号：EP0036534A1

  公开（公告）日：1981-09-30

  A drug form is provided for increasing the oral absorption of β-lactam antibiotics such as the penicillins, cephalosporins and related chemical species by the oral administration of said β-lactam antibiotics in a suitable pharmaceutically accepted excipient to which has been added a hydroxy aryl or hydroxy aralkyl acid or salt, amide or ester thereof. The hydroxyaryl or hydroxyaralkyl acid or salt, amide or ester thereof is present in the drug form in quantities sufficient to be effective in enhancing the rate of oral absorption of the β-lactam antibiotic.

  本发明提供了一种药物形式，通过将β-内酰胺类抗生素口服于适当的药学上可接受的赋形剂中，并在赋形剂中加入羟基芳基或羟基芳烷基酸或其盐、酰胺或酯，从而增加β-内酰胺类抗生素如青霉素类、头孢菌素类及相关化学物质的口服吸收。羟基芳基或羟基烷基酸或其盐、酰胺或酯在药物形式中的含量足以有效提高 β-内酰胺类抗生素的口服吸收率。
• An orally administered drug form comprising a glycosidic antibiotic and an adjuvant
  申请人：INTERx RESEARCH CORPORATION

  公开号：EP0035770A2

  公开（公告）日：1981-09-16

  A drug form is provided for increasing the oral absorption of glycosidic and related antibiotics such as marcrolide, aminoglycoside, lincomycin and anthracycline antibiotics and related chemical species by the oral administration of said glycosidic and related antibiotics in a suitable pharmaceutically accepted excipient to which has been added a hydroxyaryl or hydroxyaralkyl acid or salt amide or ester thereof. The hydroxyaryl, a hydroxyaralkyl or salt amide or ester thereof is present in the drug form in quantities sufficient to be effective in enhancing the rate of oral absorption of glycosidic and related antibiotic.

  本发明提供了一种药物剂型，用于提高糖苷类和相关抗生素（如马克隆、氨基糖苷、林可霉素和蒽环类抗生素及相关化学物质）的口服吸收率，方法是将所述糖苷类和相关抗生素置于适当的药学上可接受的赋形剂中，并在赋形剂中添加羟基芳基或羟基烷基酸或盐酰胺或酯。 药物剂型中羟基芳基、羟基烷基或盐酰胺或酯的含量足以有效提高糖苷类和相关抗生素的口服吸收率。
• An orally administered drug form comprising a polar bioactive agent and an adjuvant
  申请人：INTERx RESEARCH CORPORATION

  公开号：EP0036145A1

  公开（公告）日：1981-09-23

  A drug form is provided for increasing the oral absorption of polar bioactive agents such as xanthines, polyhydroxylic substances, zwitterions, polypeptides and organic anions and related chemical species by the oral administration of said polar bioactive agents in a suitable pharmaceutically accepted excipientto which has been added a hydroxyaromatic, hydroxyaryl or hydroxy aralkyl acid or salt amide or ester thereof. The hydroxy aryl or hydroxy aralkyl acid or salt amide or ester thereof is present in the drug form in quantities suffi- cientto be effective in enhancing the rate of oral absorption of the polar bioactive agents.

  本发明提供了一种药物剂型，用于增加极性生物活性剂（如黄嘌呤、多羟基物质、 齐聚物、多肽和有机阴离子及相关化学物质）的口服吸收，方法是将所述极性生物活性 剂口服在一种适当的药学上可接受的赋形剂中，在赋形剂中添加羟基芳基、羟基芳基或 羟基烷基酸或其酰胺盐或酯。羟基芳基或羟基烷基酸或其酰胺盐或酯在药物形式中的存在量足以有效提高极性生物活性剂的口服吸收率。
• Process for the dissolution of peptides and proteins, solutions thereby obtained and their use
  申请人：SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V.

  公开号：EP0136728A2

  公开（公告）日：1985-04-10

  Process for the dissolution of peptides and proteins in non-aqueous and mixed non-aqueous/aqueous solvents using crownethers, solutions thereby obtained and their use. Purification of proteins and/or enzymes, modification and optimisation of the activity of enzymes. Use of peptide-crownether complexes as membrane materials, use of enzyme-crownether complexes as detergents.

  使用冠醚在非水和非水/水混合溶剂中溶解肽和蛋白质的工艺，由此获得的溶液及其用途。蛋白质和/或酶的纯化、酶活性的改良和优化。将肽-冠醚复合物用作膜材料，将酶-冠醚复合物用作洗涤剂。
• Targeted enteral delivery system
  申请人：R.P. SCHERER CORPORATION

  公开号：EP0225189A2

  公开（公告）日：1987-06-10

  A capsule for oral administration of a pharmaceutically active ingredient contains a pharmaceutical composition comprising the active ingredient, for example, a peptide, an absorption promoter and usually, a carrier. The absorption promoter is capable of enhancing absorption of the active ingredient from the intestine into the bloodstream. The capsule is coated with a film forming composition, which film is sufficiently insoluble at a pH below 7 as to be capable of protecting the capsule and its contents from the digestive juices until the capsule reaches a region below the upper part of the intestine, whereupon the coating and capsule are capable of eroding or dissolving to release the active ingredient for absorption into the bloodstream.

  一种用于口服药物活性成分的胶囊含有一种药物组合物，其中包括活性成分（如肽）、吸收促进剂和载体。吸收促进剂能够促进活性成分从肠道进入血液的吸收。胶囊表面涂有一层成膜组合物，这层膜在 pH 值低于 7 时具有足够的不溶性，能够保护胶囊及其内容物不受消化液的影响，直到胶囊到达肠道上部以下的区域，此时涂层和胶囊能够被侵蚀或溶解，释放出活性成分供血液吸收。