1-(4-bromophenyl)-2-(phenylamino)ethan-1-ol | 99940-35-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-(4-bromophenyl)-2-(phenylamino)ethan-1-ol
• 英文别名: 1-(4-bromophenyl)-2-(phenylamino)ethanol；2-Anilino-1-(4-bromophenyl)ethanol
• CAS: 99940-35-9
• 化学式: C₁₄H₁₄BrNO
• 分子量: 292.175
• InChiKey: SCUMDKJYZOEIBR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-(4-bromophenyl)-1-(trimethylsilyloxy)ethylene 在 lithium aluminium tetrahydride 作用下， 以 乙醚 、 苯 为溶剂， 反应 11.0h， 生成 1-(4-bromophenyl)-2-(phenylamino)ethan-1-ol
  参考文献：
  名称：

  Synthesis of β-N-Phenylamino Alcohols and α-N-Phenylamino Acids via Reduction of the Adducts of Silyl Enol Ethers and Bis-silyl Ketene Acetals with Nitrosobenzene

  摘要：

  DOI：

  10.1055/s-1985-31177

文献信息

• Synthesis of 1,2-amino alcohols by decarboxylative coupling of amino acid derived α-amino radicals to carbonyl compounds <i>via</i> visible-light photocatalyst in water
  作者：Shulei Pan、Min Jiang、Jinjin Hu、Ruigang Xu、Xiaofei Zeng、Guofu Zhong

  DOI：10.1039/c9gc03470f

  日期：——

  coupling reaction of N-aryl amino acids with aldehydes or ketones for the synthesis of various 1,2-amino alcohols by using water as the solvent at room temperature is described. This protocol is characterised by broad substrate scopes, mild reaction conditions and amenability to gram-scale synthesis, which opens up a simple, mild but effective method to produce 1,2-amino alcohols from readily available

  描述了在室温下用水作为溶剂，N-芳基氨基酸与醛或酮的通用且有效的可见光光氧化还原催化的脱羧自由基偶联反应，用于合成各种1,2-氨基醇。该方案的特点是具有广泛的底物范围，温和的反应条件和对克级合成的适应性，这为从容易获得的起始原料生产1,2-氨基醇提供了一种简单，温和但有效的方法。
• Urushiol derivatives as biomass-based photocatalysts for the transition-metal-free synthesis of 1,2-amino alcohols
  作者：Xiaozhou Huang、Ya-Qing Hu、Cen Zhou、Ying Zheng、Xiao Zhang

  DOI：10.1039/d2gc01410f

  日期：——

  decarboxylative coupling of amino acids with aldehydes. A series of 1,2-amino alcohols are accessed in a transition-metal-free fashion under eco-friendly and redox-neutral conditions. The application of an urushiol-derived film in visible-light photoredox catalysis is also disclosed.

  从可再生和可持续资源中开发催化剂是有机合成的一个重要目标。在这里，我们展示了使用漆酚衍生物作为基于生物质的催化剂，用于可见光诱导的氨基酸与醛的脱羧偶联。在环保和氧化还原中性条件下，可以以无过渡金属的方式获得一系列 1,2-氨基醇。还公开了漆酚衍生薄膜在可见光光氧化还原催化中的应用。
• Gold-Catalyzed 1,2-Difunctionalizations of Aminoalkynes Using Only N- and O-Containing Oxidants
  作者：Anupam Mukherjee、Ramesh B. Dateer、Rupsha Chaudhuri、Sabyasachi Bhunia、Somnath Narayan Karad、Rai-Shung Liu

  DOI：10.1021/ja208150d

  日期：2011.10.5

  We report two viable routes for the 1,2difunctionalization of aminoalkynes using only oxidants. In the presence of a gold catalyst, nitrones enable the oxoamination of aminoalkynes 1 to form 2-aminoamides 2. With a suitable gold catalyst, nitrosobenzenes implement an alkyne/nitroso metathesis of the same substrates to give 2-oxoiminylamides 3. These two novel oxidations also provide 1,2-aminoalcohols with opposite regioselectivity via NaBH4 reduction in situ.
• SASAKI, TADASHI;MORI, KOHKI;OHNO, MASATOMI, SYNTHESIS, BRD, 1985, N 3, 280-282
  作者：SASAKI, TADASHI、MORI, KOHKI、OHNO, MASATOMI

  DOI：——

  日期：——