4-Hydroxy-3-nitrobenzenesulfonate

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 4-Hydroxy-3-nitrobenzenesulfonate
• 化学式: C6H4NO6S-
• 分子量: 218.17
• InChiKey: JBMAUZQHVVHPEL-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  132
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Stem cell factor
  申请人：AMGEN INC.

  公开号：EP0423980A1

  公开（公告）日：1991-04-24

  Novel stem cell factors, oligonucleotides encoding the same, and methods of production, are disclosed. Pharmaceutical compositions and methods of treating disorders involving blood cells are also disclosed.

  本研究公开了新型干细胞因子、编码这些因子的寡核苷酸以及生产方法。还公开了治疗涉及血细胞疾病的药物组合物和方法。
• Polyoxymethylene-oxyethylene copolymers in conjunction with biomolecules
  申请人：AMGEN INC.

  公开号：EP0576192A2

  公开（公告）日：1993-12-29

  Biological factors with enhanced biological activity are prepared by covalently linking a biomolecule to one or more chains of a synthetic polymer wherein the synthetic polymer is derived from the oxymethylene-oxyethylene part structure.

  通过将生物分子与合成聚合物的一条或多条链共价连接，制备具有增强生物活性的生物因子，其中合成聚合物来自氧亚甲基-氧亚乙烯部分结构。
• EMBRYO IMPLANTATION INHIBITOR
  申请人：Proteinexpress Co., Ltd.

  公开号：EP1547609A1

  公开（公告）日：2005-06-29

  For a pregnancy to be established, communication between conceptus and mother, and implantation of the conceptus on the uterine wall must occur. If a factor mediating the communication between conceptus and mother is investigated and the factor can be used to control the communication, it may be possible to develop a method for treating a disorder such as sterility or preventive measures. Contraception in a safe manner may also be provided. IP-10, which is known as a protein of 10 kDa usually induced by interferon-γ is identified as a factor that controls implantation of conceptus on the uterine wall through involving immune responses and activation of conceptus migration during an implantation period, the promotion of implantation of conceptus to the uterine wall, and chemotactic activity. Based on these finding, an agent for treating sterility, promoting pregnancy, inducing implantation of conceptus on the uterine wall, or controlling interaction between conceptus and mother is provided.

  要确定怀孕，胚胎和母体之间必须进行交流，胚胎必须在子宫壁上着床。如果研究出一种介导胚胎和母体之间交流的因素，并利用这种因素来控制交流，就有可能开发出一种治疗不育症等疾病的方法或预防措施。还可以提供安全的避孕方法。众所周知，IP-10 是一种 10 kDa 蛋白质，通常由干扰素γ 诱导，已被确定为一种因子，可通过在植入期间参与免疫反应和激活胚胎迁移、促进胚胎植入子宫壁以及趋化活性来控制胚胎在子宫壁上的植入。基于这些发现，提供了一种用于治疗不育症、促进妊娠、诱导胚胎植入子宫壁或控制胚胎与母体之间相互作用的制剂。
• Brain or heart cyclic nucleotide gated ion channel compounds and uses thereof
  申请人：The Trustees of Columbia University in the City of New York

  公开号：EP1609856A2

  公开（公告）日：2005-12-28

  The present invention provides an isolated nucleic acid encoding a BCNG protein or a portion thereof or BCNG-related protein or a portion thereof. The present invention further provides a method for identifying a nucleic acid in a sample which encodes a BCNG protein or a BCNG-related protein. The present invention also provides a method for testing whether a compound affects the expression of a BCNG protein or a BCNG-related protein. In addition, the present invention further provides a method for identifying a compound capable of interacting with a BCNG protein or a BCNG-related protein. Also, the present invention provides a method for identifying a compound capable of modulating BCNG protein or BCNG-related protein activity. Further, the present invention also provides a method of treating a condition in a subject which comprises administering to the subject an amount of the provided compound, effective to treat the condition. Finally, the present invention provides a pharmaceutical composition which comprises the provided compound and a pharmaceutically acceptable carrier.

  本发明提供了一种编码 BCNG 蛋白或其部分或 BCNG 相关蛋白或其部分的分离核酸。本发明进一步提供了一种鉴定样品中编码 BCNG 蛋白或 BCNG 相关蛋白的核酸的方法。本发明还提供了一种检测化合物是否影响 BCNG 蛋白或 BCNG 相关蛋白表达的方法。此外，本发明还进一步提供了一种用于鉴定能够与 BCNG 蛋白或 BCNG 相关蛋白相互作用的化合物的方法。同时，本发明还提供了一种鉴定能够调节 BCNG 蛋白或 BCNG 相关蛋白活性的化合物的方法。此外，本发明还提供了一种治疗受试者病症的方法，该方法包括向受试者施用一定量的所提供的化合物，以有效治疗该病症。最后，本发明提供了一种药物组合物，它包含所提供的化合物和药学上可接受的载体。
• Group B streptococcus polypeptides nucleic acids and therapeutic composition and vaccines thereof
  申请人：ST. JUDE CHILDREN'S RESEARCH HOSPITAL

  公开号：EP1810978A2

  公开（公告）日：2007-07-25

  This invention provides isolated nucleic acids encoding polypeptides comprising amino acid sequences of streptococcal matrix adhesion (Ema) polypeptides. The invention provides nucleic acids encoding Group B streptococcal Ema polypeptides EmaA, EmaB, EmaC, EmaD and EmaE. The present invention provides isolated polypeptides comprising amino acid sequences of Group B streptococcal polypeptides EmaA, EmaB, EmaC, EmaD and EmaE, including analogs, variants, mutants, derivatives and fragments thereof. Ema homologous polypeptides from additional bacterial species, including S. pneumoniae, S. pyogenes, E. faecalis and C. diptheriae are also provided. Antibodies to the Ema polypeptides and immunogenic fragments thereof are also provided. The present invention relates to the identification and prevention of infections by virulent forms of streptococci. This invention provides pharmaceutical compositions, immunogenic compositions, vaccines, and diagnostic and therapeutic methods of use of the isolated polypeptides, antibodies thereto, and nucleic acids. Assays for compounds which modulate the polypeptides of the present invention for use in therapy are also provided.

  本发明提供了编码包含链球菌基质粘附（Ema）多肽氨基酸序列的多肽的分离核酸。本发明提供编码 B 组链球菌 Ema 多肽 EmaA、EmaB、EmaC、EmaD 和 EmaE 的核酸。本发明提供包含 B 组链球菌多肽 EmaA、EmaB、EmaC、EmaD 和 EmaE 的氨基酸序列的分离多肽，包括其类似物、变体、突变体、衍生物和片段。还提供了其他细菌物种的 Ema 同源多肽，包括肺炎链球菌、产脓链球菌、粪大肠杆菌和白喉杆菌。本发明还提供了 Ema 多肽的抗体及其免疫原性片段。本发明涉及毒性链球菌感染的鉴定和预防。本发明提供了药物组合物、免疫原组合物、疫苗以及使用分离多肽、其抗体和核酸的诊断和治疗方法。本发明还提供了用于治疗的调节本发明多肽的化合物的检测方法。