N-(2-acetylthiophen-3-yl)-2-[(2-chloro-6-fluorophenyl)methylsulfanyl]acetamide

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-(2-acetylthiophen-3-yl)-2-[(2-chloro-6-fluorophenyl)methylsulfanyl]acetamide
• 化学式: C₁₅H₁₃ClFNO₂S₂
• 分子量: 357.9
• InChiKey: WGLITVOVNJUCHB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  99.7
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• METHOD OF SCREENING AGENT FOR IMPROVING MEMORY AND LEARNING ABILITY
  申请人：Astellas Pharma Inc.

  公开号：EP1589103A1

  公开（公告）日：2005-10-26

  A screening tool and a screening method of a substance which is useful as an agent for improving the memory, an agent for improving learning ability, and/or an antidementia agent; a polypeptide, a polynucleotide, a vector, and a cell which may be used in the above screening; and a novel agent for improving the memory, a novel agent for improving learning ability, and/or a novel antidementia agent are disclosed. The above screening tool is composed of a calcium-permeable nonselective cation channel or a cell expressing the channel.

  本发明公开了一种物质的筛选工具和筛选方法，该物质可用作改善记忆力的制剂、改善学习能力的制剂和/或抗痴呆制剂；一种多肽、一种多核苷酸、一种载体和一种细胞，可用于上述筛选；以及一种改善记忆力的新型制剂、一种改善学习能力的新型制剂和/或一种新型抗痴呆制剂。上述筛选工具由钙离子通道或表达该通道的细胞组成。
• Method of screening agent for improving memory and learning ability
  申请人：Sano Yorikata

  公开号：US20060116315A1

  公开（公告）日：2006-06-01

  A screening tool and a screening method of a substance which is useful as an agent for improving the memory, an agent for improving learning ability, and/or an antidementia agent; a polypeptide, a polynucleotide, a vector, and a cell which may be used in the above screening; and a novel agent for improving the memory, a novel agent for improving learning ability, and/or a novel antidementia agent are disclosed. The above screening tool is composed of a calcium-permeable nonselective cation channel or a cell expressing the channel.

  本发明公开了一种物质的筛选工具和筛选方法，该物质可用作改善记忆力的制剂、改善学习能力的制剂和/或抗痴呆制剂；一种多肽、一种多核苷酸、一种载体和一种细胞，可用于上述筛选；以及一种改善记忆力的新型制剂、一种改善学习能力的新型制剂和/或一种新型抗痴呆制剂。 上述筛选工具由钙离子通道或表达该通道的细胞组成。
• US7476508B2
  申请人：——

  公开号：US7476508B2

  公开（公告）日：2009-01-13