N-(4-aminobutyl)-isoluminol | 66612-28-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: N-(4-aminobutyl)-isoluminol
• 英文别名: 6-(4-amino-butylamino)-2,3-dihydro-phthalazine-1,4-dione；6-(4-Aminobutylamino)-2,3-dihydrophthalazine-1,4-dione
• CAS: 66612-28-0
• 化学式: C₁₂H₁₆N₄O₂
• 分子量: 248.285
• InChiKey: QFXJAYZOSATTDS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  96.2
• 氢给体数：
  4
• 氢受体数：
  4

文献信息

• SPECIFIC COMPONENT MEASURING METHOD BY SPECTRAL MEASUREMENT
  申请人：Wako Pure Chemical Industries, Ltd.

  公开号：EP1643240A1

  公开（公告）日：2006-04-05

  The present invention discloses a method for measuring an amount of an objective component to bemeasured in a sample, which comprises; preventing an electric charge in an atmosphere in a photometry chamber from transferring to the surface of a solution which generates light due to an energy variation of a substance induced by the objective component in the sample, measuring value of the light, and determining an amount of the objective component in the sample on the basis of the measured value thus obtained, and an instrument used for the method. According to the present invention, in measurement of an objective component in a sample using a spectrophotometer, problems such as between-day variation of signal values or increase of background value, etc. can be solved, and a trace component can be measured in high accuracy and high sensitivity.

  本发明公开了一种测量样品中待测客观成分含量的方法，该方法包括：防止光度测量室中大气中的电荷转移到溶液表面，该溶液因样品中客观成分引起的物质能量变化而产生光；测量光值；根据由此获得的测量值确定样品中客观成分的含量；以及用于该方法的仪器。 根据本发明，在使用分光光度计测量样品中的客观成分时，可以解决信号值的日间变化或背景值增加等问题，并且可以高精度、高灵敏度地测量痕量成分。
• MULTIMER OF EXTRACELLULAR DOMAIN OF CELL SURFACE FUNCTIONAL MOLECULE
  申请人：Kyoto University

  公开号：EP1997887A1

  公开（公告）日：2008-12-03

  As a substance which pharmacologically regulates the function of a cell surface functional molecule, a substance which has specificity and an activity or efficacy equal or superior to an antibody and does not require an advanced production technique and facility for application thereof to a pharmaceutical product has been demanded. The invention relates to a multimer of an extracellular domain of a cell surface functional molecule, particularly a tetramer of an extracellular domain of PD-1 or PD-L1. Further, the invention relates to an application of such a tetramer as a preventive and/or therapeutic agent for cancer, cancer metastasis, immunodeficiency, an infectious disease or the like and an application of PD-1 or PD-L1 as a testing or diagnostic agent or a research agent for such a disease.

  作为一种对细胞表面功能分子的功能进行药理调节的物质，人们需要一种特异性强、活性或疗效等同或优于抗体，并且不需要先进的生产技术和设备就能将其应用于医药产品的物质。本发明涉及一种细胞表面功能分子胞外结构域的多聚体，特别是 PD-1 或 PD-L1 胞外结构域的四聚体。此外，本发明还涉及这种四聚体作为癌症、癌症转移、免疫缺陷、传染性疾病或类似疾病的预防和/或治疗剂的应用，以及PD-1或PD-L1作为此类疾病的检测剂、诊断剂或研究剂的应用。
• Multimer of extracellular domain of cell surface functional molecule
  申请人：ONO Pharmaceutical Co., Ltd.

  公开号：EP2468765A1

  公开（公告）日：2012-06-27

  As a substance which pharmacologically regulates the function of a cell surface functional molecule, a substance which has specificity and an activity or efficacy equal or superior to an antibody and does not require an advanced production technique and facility for application thereof to a pharmaceutical product has been demanded. The invention relates to a multimer of an extracellular domain of a cell surface functional molecule, particularly a tetramer of an extracellular domain of PD-1 or PD-L1. Further, the invention relates to an application of such a tetramer as a preventive and/or therapeutic agent for cancer, cancer metastasis, immunodeficiency, an infectious disease or the like and an application of PD-1 or PD-L1 as a testing or diagnostic agent or a research agent for such a disease.

  作为一种对细胞表面功能分子的功能进行药理调节的物质，人们需要一种特异性强、活性或疗效等同或优于抗体，并且不需要先进的生产技术和设备就能将其应用于医药产品的物质。本发明涉及一种细胞表面功能分子胞外结构域的多聚体，特别是 PD-1 或 PD-L1 胞外结构域的四聚体。此外，本发明还涉及这种四聚体作为癌症、癌症转移、免疫缺陷、传染性疾病或类似疾病的预防和/或治疗剂的应用，以及PD-1或PD-L1作为此类疾病的检测剂、诊断剂或研究剂的应用。
• Tetramer of extracellular domain of PD-L1
  申请人：ONO Pharmaceutical Co., Ltd.

  公开号：EP2468765A9

  公开（公告）日：2014-12-31

  As a substance which pharmacologically regulates the function of a cell surface functional molecule, a substance which has specificity and an activity or efficacy equal or superior to an antibody and does not require an advanced production technique and facility for application thereof to a pharmaceutical product has been demanded. The invention relates to a multimer of an extracellular domain of a cell surface functional molecule, particularly a tetramer of an extracellular domain of PD-1 or PD-L1. Further, the invention relates to an application of such a tetramer as a preventive and/or therapeutic agent for cancer, cancer metastasis, immunodeficiency, an infectious disease or the like and an application of PD-1 or PD-L1 as a testing or diagnostic agent or a research agent for such a disease.

  作为一种对细胞表面功能分子的功能进行药理调节的物质，人们需要一种特异性强、活性或疗效等同或优于抗体，并且不需要先进的生产技术和设备就能将其应用于医药产品的物质。本发明涉及一种细胞表面功能分子胞外结构域的多聚体，特别是 PD-1 或 PD-L1 胞外结构域的四聚体。此外，本发明还涉及这种四聚体作为癌症、癌症转移、免疫缺陷、传染性疾病或类似疾病的预防和/或治疗剂的应用，以及PD-1或PD-L1作为此类疾病的检测剂、诊断剂或研究剂的应用。
• Control marker for implementing analysis methods on spots
  申请人：BIO-RAD EUROPE GMBH

  公开号：US10139404B2

  公开（公告）日：2018-11-27

  The present invention relates to the use of a control marker for implementing analysis methods on spots, in particular in the context of multiplex analyses. The present invention thus relates to solid supports containing said control marker, their preparation method and their use in analysis methods. The present invention makes it possible to verify the presence, location and/or integrity of the spots at the end of the analysis method, and thus to secure the obtained results while guaranteeing that the yielded result indeed results from a present, intact and localized spot.

  本发明涉及使用对照标记物在斑点上实施分析方法，特别是在多重分析中。因此，本发明涉及含有所述控制标记的固体支持物、其制备方法及其在分析方法中的使用。本发明可以在分析方法结束时验证斑点的存在、位置和/或完整性，从而确保所获得的结果，同时保证所产生的结果确实来自于一个存在的、完整的和定位的斑点。