N-(5-methoxy-2-pyrimidinyl)-acetamide | 4884-47-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-(5-methoxy-2-pyrimidinyl)-acetamide
• 英文别名: 2-Acetylamino-5-methoxy-pyrimidin；N-(5-methoxy-pyrimidin-2-yl)-acetamide；Acetamide, N-(5-methoxy-2-pyrimidinyl)-；N-(5-methoxypyrimidin-2-yl)acetamide
• CAS: 4884-47-3
• 化学式: C₇H₉N₃O₂
• 分子量: 167.167
• InChiKey: JIUMYKGZGQSCRK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  64.1
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• 5-Ý2-(METHYLTHIO)ETHOXY¨PYRIMIDINE-2-AMINE MANUFACTURING METHOD
  申请人：Kowa Company, Ltd.

  公开号：EP2332923A1

  公开（公告）日：2011-06-15

  A novel method for preparing 5-[2-(methylthio)ethoxylpyrimidin-2-amine useful as a regent or raw material for manufacture of medicaments, agricultural chemicals, and industrial products, which comprises alkanoylating the amino group of a 2-amino-4-alkoxypyrimidine, then converting the resultant into a 4-hydroxypyrimidine compound by a treatment with anhydrous aluminum chloride, further etherifying the 4-hydroxypyrimidine compound by a reaction with a 2-haloethyl methyl sulfide in the presence of a base, and removing the alkanoyl group to obtain 5-[2-(methylthio)ethoxylpyrimidin-2-amine.

  一种制备 5-[2-(甲硫基)乙氧基嘧啶-2-胺的新方法，可用作药物、农药和工业产品的试剂或原料，该方法包括将 2-氨基-4-烷氧基嘧啶的氨基烷酰化、然后用无水氯化铝处理，将生成物转化为 4-羟基嘧啶化合物，在碱存在下，通过与 2-卤乙基甲基硫醚反应，进一步醚化 4-羟基嘧啶化合物，并除去烷酰基，得到 5-[2-（甲硫基）乙氧基嘧啶-2-胺]。
• 3-(CARBOXYMETHYL)-8-AMINO-2-OXO-1,3-DIAZA-SPIRO-[4.5]-DECANE DERIVATIVES
  申请人：Grünenthal GmbH

  公开号：EP3402785A1

  公开（公告）日：2018-11-21
• [EN] 3-(CARBOXYMETHYL)-8-AMINO-2-OXO-1,3-DIAZA-SPIRO-[4.5]-DECANE DERIVATIVES<br/>[FR] DÉRIVÉS DE 3-(CARBOXYMÉTHYL)-8-AMINO-2-OXO-1,3-DIAZA-SPIRO-[4.5]-DÉCANE
  申请人：GRUENENTHAL GMBH

  公开号：WO2017121649A1

  公开（公告）日：2017-07-20

  The invention relates to 3-(carboxymethyl)-8-amino-2-oxo-l,3-diaza- spiro-[4.5]-decane derivatives of general formula (I), their preparation and their use in medicine, particularly in the treatment of pain.