[3-Hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl [2-(hydroxymethyl)-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl] hydrogen phosphate

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - （3'->5'）-二核苷酸和类似物
• 英文名称: [3-Hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl [2-(hydroxymethyl)-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl] hydrogen phosphate
• 化学式: C₂₀H₂₇N₄O₁₂P
• 分子量: 546.4
• InChiKey: FCXGCSBZKOHCLB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.1
• 重原子数：
  37
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  214
• 氢给体数：
  5
• 氢受体数：
  12

文献信息

• OLIGONUCLEOTIDE WITH PROTECTED BASE
  申请人：Ajinomoto Co., Inc.

  公开号：US20150080565A1

  公开（公告）日：2015-03-19

  The present invention provides a protected nucleotide for elongation, which can be purified efficiently and in a high yield by a liquid-liquid extraction operation, and can achieve an oligonucleotide production method by a phosphoramidite method. It has been found that the above-mentioned problem can be solved by a particular oligonucleotide comprising a protected base and/or particular oligonucleotide protected by a branched chain-containing aromatic group at 3′-position.

  本发明提供了一种用于延伸的保护核苷酸，可以通过液液萃取操作高效率、高产量地纯化，并可通过磷酰胺酰胺法实现寡核苷酸的生产方法。发现通过在3'-位置含有支链含芳香基团的特定寡核苷酸和/或特定寡核苷酸保护基，可以解决上述问题。
• US8846885B2
  申请人：——

  公开号：US8846885B2

  公开（公告）日：2014-09-30
• US9371353B2
  申请人：——

  公开号：US9371353B2

  公开（公告）日：2016-06-21