1-Isopropenyl-2-methoxy-naphthalin | 17212-98-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-Isopropenyl-2-methoxy-naphthalin
• 英文别名: 2-Methoxy-1-prop-1-en-2-ylnaphthalene
• CAS: 17212-98-5
• 化学式: C₁₄H₁₄O
• 分子量: 198.265
• InChiKey: OXNFUIQVVWSLKM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-(2-methoxy-1-naphthyl)-2-propanol 生成 1-Isopropenyl-2-methoxy-naphthalin
  参考文献：
  名称：

  Lapkin,I.I.; Rybakova,M.N., Journal of general chemistry of the USSR, 1960, vol. 30, p. 2656 - 2658

  摘要：

  DOI：

文献信息

• Macrocyclization reactions and intermediates and other fragments useful in the synthesis of analogs of halichondrin B
  申请人：EISAI R&D MANAGEMENT CO., LTD.

  公开号：US10934307B2

  公开（公告）日：2021-03-02

  The invention provides methods for the synthesis of eribulin or a pharmaceutically acceptable salt thereof (e.g., eribulin mesylate) through a macrocyclization strategy. The macrocyclization strategy of the present invention involves subjecting a non-macrocyclic intermediate to a carbon-carbon bond-forming reaction (e.g., an olefination reaction (e.g., Horner-Wadsworth-Emmons olefination), Dieckmann reaction, catalytic Ring-Closing Olefin Metathesis, or Nozaki-Hiyama-Kishi reaction) to afford a macrocyclic intermediate. The invention also provides compounds useful as intermediates in the synthesis of eribulin or a pharmaceutically acceptable salt thereof and methods for preparing the same.

  本发明提供了通过大环化策略合成埃里布林或其药学上可接受的盐（如甲磺酸埃里布林）的方法。本发明的大环化策略包括将非大环中间体进行碳-碳键形成反应（例如，烯化反应（例如，Horner-Wadsworth-Emmons 烯化反应）、Dieckmann 反应、催化闭环烯烃 Metathesis 或 Nozaki-Hiyama-Kishi 反应）以得到大环中间体。本发明还提供了可用作合成麦角林或其药学上可接受的盐的中间体的化合物，以及制备这些化合物的方法。
• CARNDUFF J.; BRADY P. A., J. CHEM. RES. SYNOP., 1977, NO
  作者：CARNDUFF J.、 BRADY P. A.

  DOI：——

  日期：——
• MACROCYCLIZATION REACTIONS AND INTERMEDIATES AND OTHER FRAGMENTS USEFUL IN THE SYNTHESIS OF ANALOGS OF HALICHONDRIN B
  申请人：EISAI R&D MANAGEMENT CO., LTD.

  公开号：US20190144463A1

  公开（公告）日：2019-05-16

  The invention provides methods for the synthesis of eribulin or a pharmaceutically acceptable salt thereof (e.g., eribulin mesylate) through a macrocyclization strategy. The macrocyclization strategy of the present invention involves subjecting a non-macrocyclic intermediate to a carbon-carbon bond-forming reaction (e.g., an olefination reaction (e.g., Horner-Wadsworth-Emmons olefination), Dieckmann reaction, catalytic Ring-Closing Olefin Metathesis, or Nozaki-Hiyama-Kishi reaction) to afford a macrocyclic intermediate. The invention also provides compounds useful as intermediates in the synthesis of eribulin or a pharmaceutically acceptable salt thereof and methods for preparing the same.
• US9783549B2
  申请人：——

  公开号：US9783549B2

  公开（公告）日：2017-10-10
• Lapkin,I.I.; Rybakova,M.N., Journal of general chemistry of the USSR, 1960, vol. 30, p. 2656 - 2658
  作者：Lapkin,I.I.、Rybakova,M.N.

  DOI：——

  日期：——