Piperidin-1-yl-(8-thiophen-3-yl-1,6-naphthyridin-2-yl)methanone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: Piperidin-1-yl-(8-thiophen-3-yl-1,6-naphthyridin-2-yl)methanone
• 化学式: C₁₈H₁₇N₃OS
• 分子量: 323.4
• InChiKey: PUPICQUAIIQDFH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  74.3
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• 2, 8-DISUBSTITUTED NAPHTHYRIDINE DERIVATIVES
  申请人：Serenex, Inc.

  公开号：EP1773834A2

  公开（公告）日：2007-04-18
• [EN] 2, 8-DISUBSTITUTED NAPHTHYRIDINE DERIVATIVES<br/>[FR] DERIVES DE NAPHTHYRIDINE 2, 8-DISUBSTITUES
  申请人：SERENEX INC

  公开号：WO2006017672A2

  公开（公告）日：2006-02-16

  Disclosed are compounds of formula (A) and pharmaceutically acceptable salts thereof, wherein R1, R2, R2' , R3, R21, A1, A2, X, and Z are defined herein. Compounds of formula (A) are useful in the treatment of diseases and/or conditions related to cell differentiation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.