(2Z)-2-(4'-phenyl-2H-chromen-2'-ylidene)naphthalen-1(2H)-one | 1259330-60-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 新黄酮类化合物
• 英文名称: (2Z)-2-(4'-phenyl-2H-chromen-2'-ylidene)naphthalen-1(2H)-one
• 英文别名: (2Z)-2-(4-phenylchromen-2-ylidene)naphthalen-1-one
• CAS: 1259330-60-3
• 化学式: C₂₅H₁₆O₂
• 分子量: 348.401
• InChiKey: WJQDURIXAFOYST-FLFQWRMESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  27
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (2Z)-2-(4'-phenyl-2H-chromen-2'-ylidene)naphthalen-1(2H)-one 在 盐酸 、 溶剂黄146 作用下， 生成 (2E)-2-(4'-phenyl-2H-chromen-2'-ylidene)naphthalen-1(2H)-one
  参考文献：
  名称：

  Synthesis of carbonyl dyes from 1-hydroxy-2-acetonaphthone and 2-fluorobenzophenone

  摘要：

  Abstract magnified image The reaction between 1‐hydroxy‐2‐acetonaphthone and 2‐fluorobenzophenone in basic medium afforded two diastereoisomeric carbonyl dyes whose structures were unambiguously established using spectroscopic methods. A mechanism for the formation of these dyes involving a base‐catalysed addition followed by dehydration and intramolecular aromatic nucleofilic substitution is proposed. J. Heterocyclic Chem., (2010).

  DOI：

  10.1002/jhet.434
• 作为产物：
  描述：

  2-乙酰基-1-萘酚 、 邻氟二苯甲酮 在 potassium tert-butylate 、 水 、 氯化铵 作用下， 以 甲苯 为溶剂， 反应 1.0h， 以63%的产率得到(2Z)-2-(4'-phenyl-2H-chromen-2'-ylidene)naphthalen-1(2H)-one
  参考文献：
  名称：

  Synthesis of carbonyl dyes from 1-hydroxy-2-acetonaphthone and 2-fluorobenzophenone

  摘要：

  Abstract magnified image The reaction between 1‐hydroxy‐2‐acetonaphthone and 2‐fluorobenzophenone in basic medium afforded two diastereoisomeric carbonyl dyes whose structures were unambiguously established using spectroscopic methods. A mechanism for the formation of these dyes involving a base‐catalysed addition followed by dehydration and intramolecular aromatic nucleofilic substitution is proposed. J. Heterocyclic Chem., (2010).

  DOI：

  10.1002/jhet.434

文献信息

• Synthesis of carbonyl dyes from 1-hydroxy-2-acetonaphthone and 2-fluorobenzophenone
  作者：Paulo J. Coelho、Isabel C. Fernandes、Luis M. Carvalho

  DOI：10.1002/jhet.434

  日期：——

  Abstract magnified image The reaction between 1‐hydroxy‐2‐acetonaphthone and 2‐fluorobenzophenone in basic medium afforded two diastereoisomeric carbonyl dyes whose structures were unambiguously established using spectroscopic methods. A mechanism for the formation of these dyes involving a base‐catalysed addition followed by dehydration and intramolecular aromatic nucleofilic substitution is proposed. J. Heterocyclic Chem., (2010).