Succinic acid mono-[8-(5-dimethylamino-naphthalene-1-sulfonyloxy)-octyl] ester | 601488-46-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: Succinic acid mono-[8-(5-dimethylamino-naphthalene-1-sulfonyloxy)-octyl] ester
• 英文别名: 4-[8-[5-(Dimethylamino)naphthalen-1-yl]sulfonyloxyoctoxy]-4-oxobutanoic acid；4-[8-[5-(dimethylamino)naphthalen-1-yl]sulfonyloxyoctoxy]-4-oxobutanoic acid
• CAS: 601488-46-4
• 化学式: C₂₄H₃₃NO₇S
• 分子量: 479.595
• InChiKey: OFHBPMFXFPKXEI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  33
• 可旋转键数：
  16
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  119
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  Succinic acid mono-[8-(5-dimethylamino-naphthalene-1-sulfonyloxy)-octyl] ester 在 Tenta Gel 、 达卡巴嗪 、 sodium azide 、 potassium carbonate 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 、 甲醇 为溶剂， 反应 1.0h， 以87%的产率得到8-叠氮辛烷-1-醇
  参考文献：
  名称：

  A real time reaction monitoring using fluorescent dansyl group as a solid-phase leaving group

  摘要：

  A real time monitoring method to monitor the progress of the solid-phase reaction has been developed. The substitution reaction on the solid-phase was clearly monitored as a change in the color depth using the fluorescent dansyl group as the leaving group. This methodology is applicable to both parallel and split combinatorial synthesis. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(03)01406-0
• 作为产物：
  描述：

  1,8-辛二醇 在 吡啶 、 4-二甲氨基吡啶 作用下， 以 二氯甲烷 为溶剂， 生成 Succinic acid mono-[8-(5-dimethylamino-naphthalene-1-sulfonyloxy)-octyl] ester
  参考文献：
  名称：

  A real time reaction monitoring using fluorescent dansyl group as a solid-phase leaving group

  摘要：

  A real time monitoring method to monitor the progress of the solid-phase reaction has been developed. The substitution reaction on the solid-phase was clearly monitored as a change in the color depth using the fluorescent dansyl group as the leaving group. This methodology is applicable to both parallel and split combinatorial synthesis. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(03)01406-0

文献信息

• A real time reaction monitoring using fluorescent dansyl group as a solid-phase leaving group
  作者：Toshiro Suenaga、Caroline Schutz、Tadashi Nakata

  DOI：10.1016/s0040-4039(03)01406-0

  日期：2003.7

  A real time monitoring method to monitor the progress of the solid-phase reaction has been developed. The substitution reaction on the solid-phase was clearly monitored as a change in the color depth using the fluorescent dansyl group as the leaving group. This methodology is applicable to both parallel and split combinatorial synthesis. (C) 2003 Elsevier Ltd. All rights reserved.