1-[1,2-Bis-(4-methoxy-phenyl)-butyl]-1H-[1,2,4]triazole | 145192-11-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 1-[1,2-Bis-(4-methoxy-phenyl)-butyl]-1H-[1,2,4]triazole
• 英文别名: 1-[1,2-Bis(4-methoxyphenyl)butyl]-1,2,4-triazole
• CAS: 145192-11-6
• 化学式: C₂₀H₂₃N₃O₂
• 分子量: 337.422
• InChiKey: XHLGMJPCLNXSRH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  25
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  49.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  脱氧茴香偶姻 在 lithium aluminium tetrahydride 、 sodium hydride 作用下， 以 四氢呋喃 、 乙腈 为溶剂， 反应 5.0h， 生成 1-[1,2-Bis-(4-methoxy-phenyl)-butyl]-1H-[1,2,4]triazole
  参考文献：
  名称：

  Antifungal agents. 1. Synthesis and antifungal activities of estrogen-like imidazole and triazole derivatives

  摘要：

  The synthesis of some 2-aryl-1-(4-methoxyphenyl)-1-(1H-imidazol-1-yl)ethane derivatives and related IH-1,2,4- and 1H-1,3,4-triazoles is described. The molecular structure of new derivatives has been established by IH NMR spectra and X-ray crystallographic analysis. When tested in solid agar cultures the azole derivatives showed from moderate to potent in vitro antifungal activity against Candida albicans and Candida spp.

  DOI：

  10.1016/0223-5234(92)90183-2

文献信息

• Antifungal agents. 1. Synthesis and antifungal activities of estrogen-like imidazole and triazole derivatives
  作者：S Massa、R Di Santo、A Retico、M Artico、N Simonetti、G Fabrizi、D Lamba

  DOI：10.1016/0223-5234(92)90183-2

  日期：1992.8

  The synthesis of some 2-aryl-1-(4-methoxyphenyl)-1-(1H-imidazol-1-yl)ethane derivatives and related IH-1,2,4- and 1H-1,3,4-triazoles is described. The molecular structure of new derivatives has been established by IH NMR spectra and X-ray crystallographic analysis. When tested in solid agar cultures the azole derivatives showed from moderate to potent in vitro antifungal activity against Candida albicans and Candida spp.