N-cyclopentyl-2,3-diphenylquinoxaline-6-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: N-cyclopentyl-2,3-diphenylquinoxaline-6-carboxamide
• 化学式: C₂₆H₂₃N₃O
• mdl: MFCD08317870
• 分子量: 393.5
• InChiKey: RVXSUZGJVJZTSH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  54.9
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY<br/>[FR] COMPOSITIONS ET PROCÉDÉS DE MODULATION DE L'ACTIVITÉ DE LA DÉSHYDROGÉNASE À CHAÎNE COURTE
  申请人：UNIV CASE WESTERN RESERVE

  公开号：WO2018145080A1

  公开（公告）日：2018-08-09

  Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.

  调节15-PGDH活性、调节组织前列腺素水平、治疗疾病、疾病障碍或需要调节15-PGDH活性和/或前列腺素水平的情况的化合物和调节方法包括本文所描述的15-PGDH抑制剂。
• COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE
  申请人：CASE WESTERN RESERVE UNIVERSITY

  公开号：US20200095206A1

  公开（公告）日：2020-03-26

  Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.