trimethylolpropane tris(2-hydroxypropyl-3-piperazine) | 893411-69-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: trimethylolpropane tris(2-hydroxypropyl-3-piperazine)
• 英文别名: 1-[2,2-Bis[(2-hydroxy-3-piperazin-1-ylpropoxy)methyl]butoxy]-3-piperazin-1-ylpropan-2-ol
• CAS: 893411-69-3
• 化学式: C₂₇H₅₆N₆O₆
• 分子量: 560.778
• InChiKey: ZHXIVJZDWUXJNC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.9
• 重原子数：
  39
• 可旋转键数：
  19
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  134
• 氢给体数：
  6
• 氢受体数：
  12

反应信息

• 作为反应物：
  描述：

  trimethylolpropane tris(2-hydroxypropyl-3-piperazine) 、 2,2’-[[2-乙基-2-[(环氧乙基甲氧基)甲基]-1,3-联丙基]双(氧亚甲基)]双环氧乙烷 以 甲醇 为溶剂， 反应 72.0h， 生成 1-[4-[3-[2,2-Bis[[3-[4-[3-[2,2-bis(oxiran-2-ylmethoxymethyl)butoxy]-2-hydroxypropyl]piperazin-1-yl]-2-hydroxypropoxy]methyl]butoxy]-2-hydroxypropyl]piperazin-1-yl]-3-[2,2-bis(oxiran-2-ylmethoxymethyl)butoxy]propan-2-ol
  参考文献：
  名称：

  [EN] DENDRITIC POLYMERS WITH ENHANCED AMPLIFICATION AND INTERIOR FUNCTIONALITY
  [FR] POLYMERES DENDRITIQUES AVEC FONCTIONNALITE INTERIEURE ET AMPLIFICATION RENFORCEES

  摘要：

  公开号：

  WO2006115547A3
• 作为产物：
  描述：

  哌嗪 、 2,2’-[[2-乙基-2-[(环氧乙基甲氧基)甲基]-1,3-联丙基]双(氧亚甲基)]双环氧乙烷 以 甲醇 为溶剂， 反应 20.08h， 以92%的产率得到trimethylolpropane tris(2-hydroxypropyl-3-piperazine)
  参考文献：
  名称：

  [EN] DENDRITIC POLYMERS WITH ENHANCED AMPLIFICATION AND INTERIOR FUNCTIONALITY
  [FR] POLYMERES DENDRITIQUES AVEC FONCTIONNALITE INTERIEURE ET AMPLIFICATION RENFORCEES

  摘要：

  公开号：

  WO2006115547A3

文献信息

• Dendritic polymers with enhanced amplification and interior functionality
  申请人：Dendritic Nanotechnologies Inc.

  公开号：EP2385078A1

  公开（公告）日：2011-11-09

  Dendritic polymers with enhanced amplification and interior functionality are disclosed. These dendritic polymer are made by use of fast, reactive ring opening chemistry (or other fast reactions) combined with the use of branch cell reagants in a controlled way to rapidly and precisely build dendrimer structures, generation by generation, with precise structures with cleaner chemistry, typically single products, lower excesses of reagants, lower levels of dilution, higher capacity method, more easily scale to commercial dimensions, new ranges of materials, and lower cost. The dendrimer composition prepared have novel internal functionality, greater stability, e.g., thermal stability and less or no reverse Michaels reaction, and which reach encapsulation surface densities at lower generations. Unexpectedly, these reactions of poly-functional branch cell reagents with polyfunctional surfaces do not create gelled materials. Such dendritic polymers are useful as demulsifiers for oil/water emulsions, wet strength agents in the manufacture of paper, proton scavengers, calibration standards for electron microscopy, making size selective membranes, and agents for modifying viscosity in aqueous formulations such as paint. When these dendritic polymers have a carried material associated with their surface and/or interior, then these dendritic have additional properties due to the unique characteristics of the dendritic polymer.

  本发明公开了具有增强放大和内部功能的树枝状聚合物。这些树枝状聚合物是通过使用快速、活性开环化学反应（或其他快速反应），结合使用分支细胞试剂，以受控方式快速、精确地逐代构建树枝状聚合物结构，其结构精确，化学反应更纯净，通常是单一产物，试剂过量较少，稀释程度较低，方法容量较大，更容易扩展到商业尺寸，材料范围较新，成本较低。制备的树枝状聚合物组合物具有新颖的内部官能度、更高的稳定性（如热稳定性）和更少或没有反向 Michaels 反应，并能以更低的代数达到封装表面密度。意想不到的是，这些多官能团分支细胞试剂与多官能团表面的反应不会产生胶凝材料。这种树枝状聚合物可用作油/水乳剂的破乳剂、造纸过程中的湿强度剂、质子清除剂、电子显微镜的校准标准、尺寸选择膜，以及涂料等水性配方中的粘度调节剂。当这些树枝状聚合物的表面和/或内部带有载体材料时，由于树枝状聚合物的独特特性，这些树枝状聚合物就会具有额外的性能。
• DENDRITIC POLYMERS WITH ENHANCED AMPLIFICATION AND INTERIOR FUNCTIONALITY
  申请人：Dendritic Nanotechnologies, Inc.

  公开号：EP1737899B1

  公开（公告）日：2015-07-08
• Dendritic Polymers with Enhanced Amplification and Interior Functionality
  申请人：Tomalia A. Donald

  公开号：US20070244296A1

  公开（公告）日：2007-10-18

  Poly(ester-acrylate) and poly(ester/epoxide) dendrimers. These materials can be synthesized by utilizing the so-called “sterically induced stoichiometric” principles. The preparation of the dendrimers is carried out by reacting precursor amino/polyamino-functional core materials with various branch cell reagents. The branch cell reagents are dimensionally large, relative to the amino/polyamino-initiator core and when reacted, produce generation=1 dendrimers directly in one step. There is also a method by which the dendrimers can be stabilized and that method is the reaction of the dendrimers with surface reactive molecules to pacify the reactive groups on the dendrimers.
• Dendritic Polymers With Enhanced Amplification and Interior Functionality
  申请人：Tomalia A. Donald

  公开号：US20070298006A1

  公开（公告）日：2007-12-27

  Dendritic polymers with enhanced amplification and interior functionality are disclosed. These dendritic polymers are made by use of fast, reactive ring-opening chemistry (or other fast reactions) combined with the use of branch cell reagents in a controlled way to rapidly and precisely build dendritic structures, generation by generation, with cleaner chemistry, often single products, lower excesses of reagents, lower levels of dilution, higher capacity method, more easily scaled to commercial dimensions, new ranges of materials, and lower cost. The dendritic compositions prepared have novel internal functionality, greater stability (e.g., thermal stability and less or no reverse Michael's reaction), and reach encapsulation surface densities at lower generations. Unexpectedly, these reactions of polyfunctional branch cell reagents with polyfunctional cores do not create cross-linked materials. Such dendritic polymers are useful as demulsifiers for oil/water emulsions, wet strength agents in the manufacture of paper, proton scavengers, polymers, nanoscale monomers, calibration standards for electron microscopy, making size selective membranes, and agents for modifying viscosity in aqueous formulations such as paint. When these dendritic polymers have a carried material associated with their surface and/or interior, then these dendritic polymers have additional properties for carrying materials due to the unique characteristics of the dendritic polymer, such as for drug delivery, transfection, and diagnostics.
• US7985424B2
  申请人：——

  公开号：US7985424B2

  公开（公告）日：2011-07-26