ethyl (2Z)-2-(carbamoylhydrazinylidene)propanoate | 14923-66-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: ethyl (2Z)-2-(carbamoylhydrazinylidene)propanoate
• CAS: 14923-66-1
• 化学式: C₆H₁₁N₃O₃
• 分子量: 173.172
• InChiKey: HVFVGYAKDVKQEB-YWEYNIOJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  93.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• HETEROCYCLIC SUBSTITUTED TRIFLUOROMETHYL PYRIMIDINONES AND THEIR USE
  申请人：BAYER PHARMA AKTIENGESELLSCHAFT

  公开号：US20160237059A1

  公开（公告）日：2016-08-18

  The present application relates to novel heterocyclically substituted 6-(trifluoromethyl)pyrimidin-4(3H)-one derivatives, to processes for their preparation, to their use alone or in combinations for the treatment and/or prevention of diseases, and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for treatment and/or prevention of cardiovascular, renal, inflammatory and fibrotic diseases.

  本申请涉及新颖的杂环取代的6-(三氟甲基)嘧啶-4(3H)-酮衍生物，其制备方法，它们单独或组合用于治疗和/或预防疾病，以及它们用于制备用于治疗和/或预防疾病的药物，特别是用于治疗和/或预防心血管、肾脏、炎症和纤维化疾病。
• [EN] BENZHYDROL-PYRAZOLE DERIVATIVES HAVING KINASE INHIBITORY ACTIVITY AND USES THEREOF<br/>[FR] DÉRIVÉS DE BENZHYDROL-PYRAZOLE PRÉSENTANT UNE ACTIVITÉ INHIBITRICE DE KINASE ET UTILISATIONS DE CEUX-CI
  申请人：X RX INC

  公开号：WO2013106432A1

  公开（公告）日：2013-07-18

  The present invention features benzhydrol-pyrazole derivatives and related compounds having kinase inhibitory activity. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing various medical conditions, such as cancers, inflammatory disorders, or autoimmune disorders.

  本发明涉及具有激酶抑制活性的苯甲酸苯甲酰-吡唑衍生物和相关化合物。本发明的化合物，单独或与其他药物活性剂联合使用，可用于治疗或预防各种医疗状况，如癌症、炎症性疾病或自身免疫性疾病。
• BENZHYDROL-PYRAZOLE DERIVATIVES HAVING KINASE INHIBITORY ACTIVITY AND USES THEREOF
  申请人：X-Rx., Inc.

  公开号：US20150005345A1

  公开（公告）日：2015-01-01

  The present invention features benzhydrol-pyrazole derivatives and related compounds having kinase inhibitory activity. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing various medical conditions, such as cancers, inflammatory disorders, or autoimmune disorders.

  本发明涉及具有激酶抑制活性的苯基苯并咪唑衍生物及相关化合物。本发明的化合物，单独或与其他药物活性剂联合使用，可用于治疗或预防各种医疗状况，如癌症、炎症性疾病或自身免疫性疾病。
• US8288425B2
  申请人：——

  公开号：US8288425B2

  公开（公告）日：2012-10-16
• US9394256B2
  申请人：——

  公开号：US9394256B2

  公开（公告）日：2016-07-19