7-Deaza-2'-deoxyguanosine 5'-triphosphate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并嘧啶类
• 英文名称: 7-Deaza-2'-deoxyguanosine 5'-triphosphate
• 英文别名: [[5-(2-amino-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-7-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
• 化学式: C₁₁H₁₇N₄O₁₃P₃
• 分子量: 506.19
• InChiKey: DLLXAZJTLIUPAI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5.3
• 重原子数：
  31
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  262
• 氢给体数：
  7
• 氢受体数：
  13

文献信息

• Enzymatic nucleic acid synthesis
  申请人：President and Fellows of Harvard College

  公开号：US10870872B2

  公开（公告）日：2020-12-22

  The disclosure provides methods for making a polynucleotide wherein the addition of nucleotides can be physically, chemically and/or enzymatically controlled. The methods include combining a selected nucleotide, cations, an error prone or template independent DNA polymerase at a reaction site including an initiator sequence attached thereto and having a 3′ terminal nucleotide, wherein the reaction reagents can be modulated and under conditions that allow covalent addition of one or more of a selected nucleotide to the 3′ terminal nucleotide such that the selected nucleotide becomes a 3′ terminal nucleotide, and repeating the addition step until the polynucleotide is formed.

  本公开提供了制造多核苷酸的方法，其中核苷酸的添加可以物理、化学和/或酶法控制。这些方法包括在反应位点上结合所选核苷酸、阳离子、易出错或与模板无关的 DNA 聚合酶，该反应位点包括连接其上并具有 3′末端核苷酸的启动子序列、其中，可以调节反应试剂，并在允许将一种或多种选定核苷酸共价添加到 3′末端核苷酸的条件下，使选定核苷酸成为 3′末端核苷酸，并重复添加步骤，直到形成多核苷酸。
• Enzymatic Nucleic Acid Synthesis
  申请人：President and Fellows of Harvard College

  公开号：US20190112626A1

  公开（公告）日：2019-04-18

  The disclosure provides methods for making a polynucleotide wherein the addition of nucleotides can be physically, chemically and/or enzymatically controlled. The methods include combining a selected nucleotide, cations, an error prone or template independent DNA polymerase at a reaction site including an initiator sequence attached thereto and having a 3′ terminal nucleotide, wherein the reaction reagents can be modulated and under conditions that allow covalent addition of one or more of a selected nucleotide to the 3′ terminal nucleotide such that the selected nucleotide becomes a 3′ terminal nucleotide, and repeating the addition step until the polynucleotide is formed.