1-ethoxy-3-(morpholin-4-yl)-3-phenylpropane | 143007-99-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-ethoxy-3-(morpholin-4-yl)-3-phenylpropane
• 英文别名: 4-(3-ethoxy-1-phenylpropyl)morpholine
• CAS: 143007-99-2
• 化学式: C₁₅H₂₃NO₂
• 分子量: 249.353
• InChiKey: VNLKBGAGVQEYEX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  21.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (3-乙氧基丙基)苯 在 三氯溴甲烷 、 (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate 作用下， 以 二氯甲烷 为溶剂， 生成 1-ethoxy-3-(morpholin-4-yl)-3-phenylpropane
  参考文献：
  名称：

  Visible-light-mediated benzylic sp3 C–H bond functionalization to C–Br or C–N bond

  摘要：

  A visible-light-promoted functionalization of unactivated benzylic sp(3) C-H bonds was developed. Ethylbenzene derivatives were converted to the corresponding benzyl bromides or afforded benzylamine derivatives in a one-pot manner under visible light photoredox conditions. (C) 2016 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2016.04.036

文献信息

• Additions of 1-(.alpha.-aminoalkyl)benzotriazoles to enol ethers. New routes to 1,3-amino ethers
  作者：Alan R. Katritzky、Stanislaw Rachwal、Bogumila Rachwal、Peter J. Steel

  DOI：10.1021/jo00044a031

  日期：1992.8

  1-(alpha-Aminoalkyl)benzotriazoles add readily to enol ethers to give the corresponding 1-benzotriazolyl-3-aminoalkyl ethers in high yields. Subsequent replacement of the benzotriazole moiety by an alkyl or aryl group (with a Grignard reagent) or by a hydrogen atom (with lithium aluminum hydride) affords 1,3-amino-ethers in good yields. Anchimeric assistance by the amino groups in the substitutions of the benzotriazolyl moiety facilitates the reactions. Full stereochemistry is assigned to the stereoisomeric products on the basis of NMR techniques and X-ray diffraction.
• Visible-light-mediated benzylic sp3 C–H bond functionalization to C–Br or C–N bond
  作者：Tianyuan Hou、Ping Lu、Pixu Li

  DOI：10.1016/j.tetlet.2016.04.036

  日期：2016.5

  A visible-light-promoted functionalization of unactivated benzylic sp(3) C-H bonds was developed. Ethylbenzene derivatives were converted to the corresponding benzyl bromides or afforded benzylamine derivatives in a one-pot manner under visible light photoredox conditions. (C) 2016 Elsevier Ltd. All rights reserved.