2-amino-1-heptanol | 93491-96-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-amino-1-heptanol
• 英文别名: 2-Aminoheptan-1-ol
• CAS: 93491-96-4
• 化学式: C₇H₁₇NO
• 分子量: 131.218
• InChiKey: PKGKENZMQLXYCF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  9
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  46.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-amino-1-heptanol 在 potassium carbonate 作用下， 以 乙腈 为溶剂， 生成 2-Benzylamino-heptanal
  参考文献：
  名称：

  4,5-Disubstituted-1,3-oxazolidin-2-imine derivatives: a new class of orally bioavailable nitric oxide synthase inhibitor

  摘要：

  In our search for a novel class of inducible nitric oxide synthase (NOS) inhibitors, 1,3-oxazolidin-2-imine was found to weakly inhibit iNOS. Further modifications of this compound resulted in a remarkable increase in both the in vivo and in vitro inhibitory activity and selectivity for iNOS. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2003.11.010
• 作为产物：
  描述：

  2-氨基庚酸 生成 2-amino-1-heptanol
  参考文献：
  名称：

  酶抑制剂Ⅳ：桥接腺苷脱氨酶上的疏水和亲水区域。

  摘要：

  DOI：

  10.1002/jps.2600600818

文献信息

• Ataxia Telengiectasia And RAD3-Related (ATR) Inhibitors And Methods Of Their Use
  申请人：Atrin Pharmaceuticals LLC

  公开号：US20170291911A1

  公开（公告）日：2017-10-12

  The disclosure is directed to compounds and compositions that inhibit Ataxia Telengiectasia And Rad3-Related (ATR) Protein Kinase and methods of their use.

  该披露涉及抑制共济失调毛细血管扩张性和Rad3相关蛋白激酶（ATR）的化合物和组合物，以及它们的使用方法。
• PROCESS FOR PREPARING DI-, TRI- AND POLYAMINES BY HOMOGENEOUSLY CATALYZED ALCOHOL AMINATION
  申请人：SCHAUB Thomas

  公开号：US20120232293A1

  公开（公告）日：2012-09-13

  Process for preparing primary amines which have at least one functional group of the formula (—CH 2 —NH 2 ) and at least one further primary amino group by alcohol amination of starting materials having at least one functional group of the formula (—CH 2 —OH) and at least one further functional group (—X), where (—X) is selected from among hydroxyl groups and primary amino groups, by means of ammonia with elimination of water, wherein the reaction is carried out homogeneously catalyzed in the presence of at least one complex catalyst comprising at least one element selected from groups 8, 9 and 10 of the Periodic Table and also at least one donor ligand.

  通过醇胺化起始物质制备至少具有一个功能基团（—CH2—NH2）和至少一个进一步的初级氨基基团的初级胺的过程，其中起始物质至少具有一个功能基团（— —OH）和至少一个进一步的功能基团（—X），其中（—X）从羟基和初级氨基中选择，通过氨与水的消除，反应在至少包含来自周期表8、9和10族中选择的至少一个元素以及至少一个给体配体的至少一个复合催化剂的存在下均匀催化进行。
• [EN] ARYL-ETHANOLAMINE DERIVATIVES AS ANTIVIRAL AGENTS<br/>[FR] DERIVES D'ARYL-ETHANOLAMINE EN TANT QU'AGENTS ANTIVIRAUX
  申请人：UPJOHN CO

  公开号：WO2004022568A1

  公开（公告）日：2004-03-18

  The present invention provides a compound of formula as describedherein, which are useful as antiviral agents, in particular, as agents against viruses of the herpes family.

  本发明提供了一种如下所述的化合物，该化合物可用作抗病毒剂，特别是用作抗疱疹病毒家族的药剂。
• [EN] NITRATED HYDROCARBONS, DERIVATIVES, AND PROCESSES FOR THEIR MANUFACTURE<br/>[FR] HYDROCARBURES NITRÉS, DÉRIVÉS ET LEURS PROCÉDÉS DE PRODUCTION
  申请人：ANGUS CHEMICAL

  公开号：WO2009129097A1

  公开（公告）日：2009-10-22

  Provided is a process for the formation of nitrated compounds by the nitration of hydrocarbon compounds with dilute nitric acid. Also provided are processes for preparing industrially useful downstream derivatives of the nitrated compounds, as well as novel nitrated compounds and derivatives, and methods of using the derivatives in various applications.

  提供了一种通过稀硝酸对碳氢化合物进行硝化形成硝化化合物的过程。还提供了制备工业上有用的硝化化合物下游衍生物的过程，以及新颖的硝化化合物和衍生物，以及在各种应用中使用衍生物的方法。
• PROCESS FOR THE PREPARATION OF PRIMARY AMINES BY HOMOGENEOUSLY CATALYZED ALCOHOL AMINATION
  申请人：SCHAUB Thomas

  公开号：US20120232292A1

  公开（公告）日：2012-09-13

  Process for the preparation of primary amines which have at least one functional group of the formula (—CH 2 —NH 2 ) by alcohol amination of starting materials which have at least one functional group of the formula (—CH 2 —OH), with ammonia, with the elimination of water, where the alcohol amination is carried out under homogeneous catalysis in the presence of at least one complex catalyst which comprises at least one element selected from groups 8 and 9 of the Periodic Table of the Elements, and also at least one phosphorus donor ligand of the general formula (I).

  通过使用至少一个来自元素周期表第8和第9族的元素选定的至少一个元素组成的至少一个复合催化剂，在存在至少一个磷供体配体的情况下，在消除水的情况下，通过对至少一个具有式（—CH2—OH）的起始材料进行醇胺化，使用氨制备至少具有一个式（— —NH2）的官能团的初级胺的方法。