N-pyrimidin-2-ylhexanamide

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-pyrimidin-2-ylhexanamide
• 化学式: C₁₀H₁₅N₃O
• mdl: MFCD01353793
• 分子量: 193.25
• InChiKey: ZAFYVKGUCFBTOK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  54.9
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Mitofusin activators and methods of use thereof
  申请人：MITOCHONDRIA EMOTION, INC.

  公开号：US11026904B2

  公开（公告）日：2021-06-08

  Compositions including small molecule mitofusin activators are described. The mitofusin activators are useful for treating diseases or disorders associated with a mitochondria-associated disease, disorder, or condition such as diseases or disorders associated with mitofusin 1 (MFN1) and/or mitofusin 2 (MFN2), or mitochondrial dysfunction. Methods of treatment, pharmaceutical formulations, and screening methods for identifying compounds that activate mitochondrial fusion are also described.

  本文描述了包括小分子丝裂霉素激活剂的组合物。丝裂磷蛋白激活剂可用于治疗与线粒体相关的疾病或失调，如与丝裂磷蛋白1（MFN1）和/或丝裂磷蛋白2（MFN2）或线粒体功能障碍相关的疾病或失调。此外，还介绍了治疗方法、药物制剂以及用于鉴定激活线粒体融合的化合物的筛选方法。
• MITOFUSIN ACTIVATORS AND METHODS OF USE THEREOF
  申请人：MITOCHONDRIA EMOTION, INC.

  公开号：US20200345669A1

  公开（公告）日：2020-11-05

  Compositions including small molecule mitofusin activators are described. The mitofusin activators are useful for treating diseases or disorders associated with a mitochondria-associated disease, disorder, or condition such as diseases or disorders associated with mitofusin 1 (MFN1) and/or mitofusin 2 (MFN2), or mitochondrial dysfunction. Methods of treatment, pharmaceutical formulations, and screening methods for identifying compounds that activate mitochondrial fusion are also described.