3,5-Dibromo-1-hydroxy-2,2,6,6-tetramethylpiperidin-4-one | 66314-86-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3,5-Dibromo-1-hydroxy-2,2,6,6-tetramethylpiperidin-4-one
• CAS: 66314-86-1
• 化学式: C₉H₁₅Br₂NO₂
• 分子量: 329.03
• InChiKey: LIAOQMDOLHMEGN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Neue Nitroxylverbindungen, Verfahren zu deren Herstellung und diese enthaltende diagnostische Mittel
  申请人：SCHERING AKTIENGESELLSCHAFT

  公开号：EP0133674B1

  公开（公告）日：1989-09-20
• IDENTIFICATION AND USE OF COMPOUNDS THAT AFFECT THE FIDELITY OF EUKARYOTIC TRANSLATION INITIATION CODON SELECTION
  申请人：Lorsch Jon R.

  公开号：US20110230451A1

  公开（公告）日：2011-09-22

  A screening method for identifying compounds that alter the fidelity with which the initiation codon in mRNAs is recognized by the translational apparatus in eukaryotes is disclosed. This screening method was used to identify compounds having such activity. Methods of altering the fidelity of initiation codon selection are also disclosed. Methods of treating disorders characterized by single nucleotide mutations in initiation codons using compounds identified by the screening method, as well as methods of treating fungal and parasitic infections and hyperproliferative disorders using compounds identified by the screening method are also disclosed.
• US8828976B2
  申请人：——

  公开号：US8828976B2

  公开（公告）日：2014-09-09