The use of substituted pyrazolo[1,5-a]pyrimidines for modulating the activity of 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) and the use of these compounds as pharmaceutical compositions are described. Also a novel class of substituted pyrazolo[1,5-a]pyrimidines their use in therapy, pharmaceutical compositions comprising the compounds, as well as their use in the manufacture of medicaments are described The present compounds are modulators and more specifically inhibitors of the activity of 11βHSD1 and may be useful in the treatment, prevention and/or prophylaxis of a range of medical disorders where a decreased intracellular concentration of active glucocorticoid is desirable.
描述了取代的
吡唑并[1,5-a]
嘧啶在调节 11β- 羟类
固醇脱氢酶 1 型(11βH
SD1)活性方面的用途,以及这些化合物作为药物组合物的用途。此外,还介绍了一类新型的取代
吡唑并[1,5-a]
嘧啶,它们在治疗中的用途、包含这些化合物的药物组合物以及它们在制造药物中的用途。本化合物是 11βH
SD1 活性的调节剂,更具体地说是
抑制剂,可用于治疗、预防和/或预防一系列需要降低细胞内活性糖
皮质激素浓度的疾病。