N-[3-cyano-6-(2-methylbutan-2-yl)-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-3-methylbutanamide

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-[3-cyano-6-(2-methylbutan-2-yl)-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-3-methylbutanamide
• 化学式: C₁₉H₂₈N₂OS
• 分子量: 332.5
• InChiKey: JNBAXDBVAHLUMJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  81.1
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Method of treating diabetes and related conditions
  申请人：Duffy Joseph

  公开号：US20060035958A1

  公开（公告）日：2006-02-16

  The present invention addresses the use of substituted thiophene derivatives, as well as compositions containing such compounds for treating type 2 diabetes mellitus. The compounds in the present invention are glucagon antagonists. The compounds block the action of glucagon at its receptor and thereby decrease the levels of plasma glucose providing a treatment of diabetes.

  本发明涉及使用取代噻吩衍生物以及含有这些化合物的组合物来治疗2型糖尿病。本发明中的化合物是胰高血糖素拮抗剂。这些化合物阻止胰高血糖素在其受体上的作用，从而降低血浆葡萄糖水平，提供糖尿病治疗。
• METHOD OF TREATING DIABETES AND RELATED CONDITIONS
  申请人：Merck & Co., Inc.

  公开号：EP1538903A2

  公开（公告）日：2005-06-15
• [EN] METHOD OF TREATING DIABETES AND RELATED CONDITIONS<br/>[FR] METHODE DE TRAITEMENT DU DIABETE ET D'ETATS ASSOCIES
  申请人：MERCK & CO INC

  公开号：WO2004024066A2

  公开（公告）日：2004-03-25

  The present invention addresses the use of substituted thiophene derivatives, as well as compositions containing such compounds for treating type 2 diabetes mellitus. The compounds in the present invention are glucagon antagonists. The compounds block the action of glucagon at its receptor and thereby decrease the levels of plasma glucose providing a treatment of diabetes.