N'-(4-乙基氨基丁基)-N-[4-(4-乙基氨基丁基氨基)丁基]丁烷-1,4-二胺 | 147510-59-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: N'-(4-乙基氨基丁基)-N-[4-(4-乙基氨基丁基氨基)丁基]丁烷-1,4-二胺
• 英文名称: 3,8,13,18,23-Pentaazapentacosane
• 英文别名: N-ethyl-N'-[4-[4-[4-(ethylamino)butylamino]butylamino]butyl]butane-1,4-diamine
• CAS: 147510-59-6
• 化学式: C₂₀H₄₇N₅
• 分子量: 357.6
• InChiKey: NPPQUDMGFNXAFH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  25
• 可旋转键数：
  22
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  60.2
• 氢给体数：
  5
• 氢受体数：
  5

文献信息

• [EN] POLYAMINE ANALOGS THAT ACTIVATE ANTIZYME FRAMESHIFTING<br/>[FR] ANALOGUES DE POLYAMINE QUI ACTIVENT LE DEPHASAGE ANTI-ENZYME
  申请人：MEDIQUEST THERAPEUTICS INC

  公开号：WO2005105729A1

  公开（公告）日：2005-11-10

  Novel polyamines, their synthesis and use in pharmacological, cosmetic or agricultural applications are provided. The polyamines induce antizyme production which in turn down regulates both the production of polyamines by ornithine decarboxylase (ODC) and the transport of polyamines by its corresponding polyamine transporter. These compounds will preferably enter the cell independent of the polyamine transporter. As drugs, these compounds are used to treat any disease associated with cellular proliferation including but not limited to cancer.

  本发明提供了新型多胺化合物的合成及其在药物、化妆品或农业应用中的使用。这些多胺化合物能够诱导抗酶的产生，从而下调鸟氨酸脱羧酶（ODC）产生的多胺化合物以及相应的多胺转运蛋白对多胺的运输。这些化合物将优先独立于多胺转运蛋白进入细胞。作为药物，这些化合物被用于治疗与细胞增殖有关的任何疾病，包括但不限于癌症。
• [EN] BIOACTIVE POLYMERS<br/>[FR] POLYMERES BIOACTIFS
  申请人：UNIV GLASGOW

  公开号：WO2006040579A1

  公开（公告）日：2006-04-20

  Various polymers, including cationic polyamine polymers and dendrimeric polymers, are shown to possess anti-proliferative activity, and may therefore be useful for treatment of disorders characterised by undesirable cellular proliferation such as neoplasms and tumours, inflammatory disorders (including autoimmune disorders), psoriasis and atherosclerosis. The polymers may be used alone as active agents, or as delivery vehicles for other therapeutic agents, such as drug molecules or nucleic acids for gene therapy. In such cases, the polymers' own intrinsic anti-tumour activity may complement the activity of the agent to be delivered.

  多种聚合物，包括阳离子聚胺聚合物和树状聚合物，被证明具有抗增殖活性，因此可能对治疗以不良细胞增殖为特征的疾病，如肿瘤和癌症、炎症性疾病（包括自身免疫性疾病）、银屑病和动脉粥样硬化等有用。这些聚合物可以单独用作活性剂，也可以作为其他治疗剂的载体，例如药物分子或用于基因治疗的核酸。在这种情况下，聚合物本身的抗肿瘤活性可以补充要传递的药剂的活性。
• AMINOQUINOLINE DERIVATIVES AND USES THEREOF
  申请人：THE MCLEAN HOSPITAL CORPORATION

  公开号：US20150023930A1

  公开（公告）日：2015-01-22

  Described herein are aminoquinoline and aminoacridine based hybrids, pharmaceutical compositions and medicaments that include such aminoquinoline and aminoacridine based hybrids, and methods of using such compounds for diagnosing and/or treating infections, neurodegerative diseases or disorders, inflammation, inflammation associated diseases and disorders, and/or diseases or disorders that are treatable with dopamine agonists such as the restless leg syndrome.

  本文描述了基于氨基喹啉和氨基蒽醌的混合物，包括含有这种基于氨基喹啉和氨基蒽醌的混合物的制药组合物和药物，以及使用这种化合物诊断和/或治疗感染、神经退行性疾病或障碍、炎症、与炎症相关的疾病和障碍以及可用多巴胺激动剂治疗的疾病或障碍（如不宁腿综合征）的方法。
• Polyamine analogs that activate antizyme framshifting
  申请人：MediQuest Therapeutics, Inc.

  公开号：US20040058954A1

  公开（公告）日：2004-03-25

  Novel polyamines, their synthesis and use in pharmacological, cosmetic or agricultural applications are provided. The polyamines induce antizyme production which in turn down regulates both the production of polyamines by ornithine decarboxylase (ODC) and the transport of polyamines by its corresponding polyamine transporter. These compounds will preferably enter the cell independent of the polyamine transporter. As drugs, these compounds are used to treat any disease associated with cellular proliferation including but not limited to cancer.

  本发明提供了新型多胺化合物及其合成方法，可用于药物、化妆品或农业应用。这些多胺化合物可诱导抗酶的产生，从而下调鸟氨酸脱羧酶（ODC）产生的多胺化合物和对应的多胺转运体的转运。这些化合物最好能够独立于多胺转运体进入细胞。作为药物，这些化合物可用于治疗与细胞增殖有关的任何疾病，包括但不限于癌症。
• Polyamine analogs that activate antizyme frameshifting
  申请人：MediQuest Therapeutics, Inc.

  公开号：US20040209926A1

  公开（公告）日：2004-10-21

  Novel polyamines, their synthesis and use in pharmacological, cosmetic or agricultural applications are provided. The polyamines induce antizyme production which in turn down regulates both the production of polyamines by omithine decarboxylase (ODC) and the transport of polyamines by its corresponding polyamine transporter. These compounds will preferably enter the cell independent of the polyamine transporter. As drugs, these compounds are used to treat any disease associated with cellular proliferation including but not limited to cancer.

  提供新型多胺，其合成和用于药物、化妆品或农业应用。多胺诱导抗酶的产生，从而下调通过鸟氨酸脱羧酶（ODC）产生多胺和多胺转运体运输多胺的产生。这些化合物将优先进入细胞，而不依赖于多胺转运体。作为药物，这些化合物用于治疗与细胞增殖有关的任何疾病，包括但不限于癌症。