(2E)-1,1,3-trimethyl-2-[5-(1,1,3-trimethylbenzo[e]indol-3-ium-2-yl)penta-2,4-dienylidene]benzo[e]indole | 54389-97-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (2E)-1,1,3-trimethyl-2-[5-(1,1,3-trimethylbenzo[e]indol-3-ium-2-yl)penta-2,4-dienylidene]benzo[e]indole
• CAS: 54389-97-8
• 化学式: C₃₅H₃₅N₂
• 分子量: 483.676
• InChiKey: ZBKIEXOQKDKCAE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.8
• 重原子数：
  37
• 可旋转键数：
  3
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  6.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1,1,3-trimethyl-2-[5-(1,1,3-trimethyl-2H-benzo[e]indol-2-yl)penta-2,4-dienylidene]benzo[e]indole 在 potassium superoxide 作用下， 以 甲醇 、 二甲基亚砜 为溶剂， 反应 1.0h， 生成 (2E)-1,1,3-trimethyl-2-[5-(1,1,3-trimethylbenzo[e]indol-3-ium-2-yl)penta-2,4-dienylidene]benzo[e]indole
  参考文献：
  名称：

  氢菁：一类可以对细胞培养、组织和体内的活性氧物质进行成像的荧光传感器

  摘要：

  准确且可调：标题化合物可以检测细胞培养物、组织外植体中的活性氧 (ROS)，这是首次在体内检测。氢花青是通过用 NaBH 4还原花青染料来合成的。它们可以准确检测纳摩尔水平的 ROS，对自氧化具有出色的稳定性，并且具有 560-830 nm 范围内的可调发射波长。

  DOI：

  10.1002/anie.200804851

文献信息

• MACROPHAGE IDENTIFICATION AGENT, AND IDENTIFICATION METHOD, SORTING METHOD, EVALUATION METHOD, SCREENING METHOD AND KIT USING THE MACROPHAGE IDENTIFIER AGENT
  申请人：CANON KABUSHIKI KAISHA

  公开号：US20160018389A1

  公开（公告）日：2016-01-21

  An object of the present invention is to provide an identification method for a macrophage subtype using an organic compound. Another object of the present invention is to provide a macrophage identification agent containing an organic compound in which a spectral characteristic obtained when the organic compound is added is different depending on a macrophage subtype. Still another object of the present invention is to provide an evaluation method for a macrophage subtype using a macrophage identification agent, an analysis method for correlation between a macrophage subtype and a test substance, a screening method for correlation between a macrophage subtype and a test substance, and a kit. An identification method for a macrophage subtype utilizing that a spectral characteristic obtained with an organic compound added is different depending on a macrophage subtype is provided.

  本发明的一个目的是提供一种利用有机化合物对巨噬细胞亚型进行识别的方法。本发明的另一个目的是提供一种巨噬细胞识别试剂，其中当添加有机化合物时得到的光谱特征取决于巨噬细胞亚型而不同。本发明的另一个目的是提供一种利用巨噬细胞识别试剂进行巨噬细胞亚型评估的方法，一种用于巨噬细胞亚型与测试物之间相关性分析的方法，一种用于巨噬细胞亚型与测试物之间相关性筛选的方法，以及一种试剂盒。提供了一种利用添加有机化合物得到的光谱特征不同取决于巨噬细胞亚型的巨噬细胞亚型识别方法。
• [EN] CANCER CELL INHIBITORY DRUG AND CANCER STEM-CELL DETECTION PROBE<br/>[FR] MÉDICAMENT INHIBITEUR DE CELLULES CANCÉREUSES ET SONDE DE DÉTECTION DE CELLULES SOUCHES CANCÉREUSES
  申请人：CANON KK

  公开号：WO2014065439A1

  公开（公告）日：2014-05-01

  An object of the present invention is to provide a cancer cell inhibitory drug, particularly a cancer stem-cell inhibitory drug, or a cancer stem-cell detection probe. The present invention provides a cancer cell inhibitory drug comprising at least one compound represented by general formula (1) as an active ingredient.

  本发明的目的是提供一种癌细胞抑制药物，特别是一种癌干细胞抑制药物，或一种癌干细胞检测探针。本发明提供了一种包含至少一种以通式（1）表示的化合物作为活性成分的癌细胞抑制药物。
• Reagent for sample analysis, kit for sample analysis and method for sample analysis
  申请人：SYSMEX CORPORATION

  公开号：EP1865318A1

  公开（公告）日：2007-12-12

  A reagent for measuring basophils and/or nucleated red blood cells in a sample, which comprises at least one fluorescent dye defined in the formula (I) or (II) is disclosed. Also disclosed are a kit and method for measuring basophils and/or nucleated red blood cells.

  本发明公开了一种用于测量样品中嗜碱性粒细胞和/或有核红细胞的试剂，该试剂包含至少一种定义在式 (I) 或 (II) 中的荧光染料。还公开了一种用于测量嗜碱性粒细胞和/或有核红细胞的试剂盒和方法。
• OPTICAL RECORDING MATERIAL AND CYANINE COMPOUND
  申请人：Adeka Corporation

  公开号：EP2020302A1

  公开（公告）日：2009-02-04

  An optical recording material comprising at least one kind of a cyanine compound represented by the following general formula (I): wherein ring A and ring B each independently represent a benzene ring or a naphthalene ring which may have a substituent ; R1 represents a group represented by the general formula (II), (II') or (II"); R2, R3 and R4 each independently represent a hydrogen atom, an organic group having 1 to 30 carbon atoms, or a group represented by the general formula (II), (II') or (II"); R3 and R4 may be linked together to form a ring structure; Y1 and Y2 each independently represent an organic group having 1 to 30 carbon atoms or a group represented by the general formula (III); X represents a hydrogen atom, a halogen atom, an alkyl group having 1 to 4 carbon atoms, a phenyl group which may have a substituent, a benzyl group which may have a substituent, or a cyano group; Anm- represents an m-valent anion; m is 1 or 2; and p represents a coefficient keeping the charge neutral.

  一种光学记录材料，包含至少一种由以下通式 (I) 表示的氰化合物： 其中环 A 和环 B 各自独立地代表一个苯环或一个萘环，它们可以具有一个取代基；R1 代表一个由通式（II）、（II'）或（II"）表示的基团；R2、R3 和 R4 各自独立地代表一个氢原子、一个具有 1 至 30 个碳原子的有机基团或一个由通式（II）、（II'）或（II"）表示的基团；R3 和 R4 可以连接在一起形成一个环结构；Y1 和 Y2 各自独立地代表具有 1 至 30 个碳原子的有机基团或通式 (III) 所代表的基团；X 代表氢原子、卤素原子、具有 1 至 4 个碳原子的烷基、可能具有取代基的苯基、可能具有取代基的苄基或氰基；Anm- 代表 m 价阴离子；m 为 1 或 2；p 代表保持电荷中性的系数。
• Macrophage identification agent, and identification method, sorting method, evaluation method, screening method and kit using the macrophage identifier agent
  申请人：CANON KABUSHIKI KAISHA

  公开号：US10041937B2

  公开（公告）日：2018-08-07

  An object of the present invention is to provide an identification method for a macrophage subtype using an organic compound. Another object of the present invention is to provide a macrophage identification agent containing an organic compound in which a spectral characteristic obtained when the organic compound is added is different depending on a macrophage subtype. Still another object of the present invention is to provide an evaluation method for a macrophage subtype using a macrophage identification agent, an analysis method for correlation between a macrophage subtype and a test substance, a screening method for correlation between a macrophage subtype and a test substance, and a kit. An identification method for a macrophage subtype utilizing that a spectral characteristic obtained with an organic compound added is different depending on a macrophage subtype is provided.

  本发明的一个目的是提供一种利用有机化合物识别巨噬细胞亚型的方法。本发明的另一个目的是提供一种含有有机化合物的巨噬细胞识别剂，其中添加有机化合物时获得的光谱特性因巨噬细胞亚型的不同而不同。本发明的另一个目的是提供一种使用巨噬细胞鉴定剂的巨噬细胞亚型的评估方法、巨噬细胞亚型与测试物质之间相关性的分析方法、巨噬细胞亚型与测试物质之间相关性的筛选方法和试剂盒。本发明提供了一种巨噬细胞亚型的鉴别方法，该方法利用了添加有机化合物后获得的光谱特性随巨噬细胞亚型的不同而不同的特点。