4-fluoro-2-[(1R)-1-(propylamino)ethyl]phenol

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 4-fluoro-2-[(1R)-1-(propylamino)ethyl]phenol
• 化学式: C₁₁H₁₆FNO
• 分子量: 197.25
• InChiKey: JVOWBUJBGCLYOJ-MRVPVSSYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• MACROCYCLIC KINASE INHIBITOR
  申请人：HITGEN INC.

  公开号：US20210147443A1

  公开（公告）日：2021-05-20

  Disclosed is a macrocyclic kinase inhibitor, wherein the compound, or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof is as shown in formula I. Experiments show that the new compound as shown in formula I disclosed in the present invention exhibits an excellent TRK inhibitory activity, has a significant inhibitory effect on TRKA-mutant cell growth, and exhibits an excellent inhibitory effect on in vivo tumor growth, thus providing a new choice for the clinical treatment of diseases associated with abnormal TRK activity.