4-Aminooestronmethylether | 13010-21-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 4-Aminooestronmethylether
• 英文别名: 4-Amino-oestron-3-methylether；4-amino-3-methoxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one
• CAS: 13010-21-4
• 化学式: C₁₉H₂₅NO₂
• 分子量: 299.413
• InChiKey: LLYYQDZHTOXRGW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  52.3
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Target directed chemotherapy of tumours of the sexual organs
  申请人：Forster Heinz

  公开号：US20070099876A1

  公开（公告）日：2007-05-03

  The invention relates to dialkyltriazene-bearing estrogens and anti-estrogens that are suited for use as chemotherapeutic drugs for treating carcinomas of the sexual organs of humans and animals.

  该发明涉及含有二烷基三氮烯的雌激素和抗雌激素，适用于作为化疗药物治疗人类和动物的生殖器癌症。
• Microrna modulators and method for identifying and using the same
  申请人：Huang Qihong

  公开号：US20100196357A1

  公开（公告）日：2010-08-05

  The present invention is a method for identifying agents which modulate microRNA activity. The invention involves contacting a cell harboring a microRNA and a microRNA binding sequence, which is operably linked to a nucleic acid molecule encoding a reporter protein, with a test agent and determining whether the test agent increases or decreases the expression of the reporter protein thereby identifying a microRNA modulator. Antagonists identified by this screening assay are provided, as are methods for using the same to inhibit microRNA activity and prevent or treat disease.
• MicroRNA Modulators and Method for Identifying and Using the Same
  申请人：Huang Qihong

  公开号：US20100317628A1

  公开（公告）日：2010-12-16

  The present invention is a method for identifying agents which modulate microRNA activity. The invention involves contacting a cell harboring a microRNA and a microRNA binding sequence, which is operably linked to a nucleic acid molecule encoding a reporter protein, with a test agent increases or decreases the expression of the reporter protein thereby identifying a microRNA modulator. Antagonists identified by this screening assay are provided, as are methods for using the same to inhibit microRNA activity and prevent or treat disease.
• US8338392B2
  申请人：——

  公开号：US8338392B2

  公开（公告）日：2012-12-25
• [EN] MICRORNA MODULATORS AND METHOD FOR IDENTIFYING AND USING THE SAME<br/>[FR] MODULATEURS DE MICRO-ARN ET PROCÉDÉ D'IDENTIFICATION ET D'UTILISATION ASSOCIÉ
  申请人：WISTAR INST

  公开号：WO2010051048A1

  公开（公告）日：2010-05-06

  The present invention is a method for identifying agents which modulate microRNA activity. The invention involves contacting a cell harboring a microRNA and a microRNA binding sequence, which is operably linked to a nucleic acid molecule encoding a reporter protein, with a test agent and determining whether the test agent increases or decreases the expression of the reporter protein thereby identifying a microRNA modulator. Antagonists identified by this screening assay are provided, as are methods for using the same to inhibit microRNA activity and prevent or treat disease.