1ξ-Amino-5α-cholestan | 806651-29-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 1ξ-Amino-5α-cholestan
• 英文别名: (5R,8S,9S,10S,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-1-amine
• CAS: 806651-29-6
• 化学式: C₂₇H₄₉N
• 分子量: 387.693
• InChiKey: NMGUVCBQWZDNOG-PMPOMGLLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.3
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1ξ-Amino-5α-cholestan 生成 5α-cholestan-1α-ol
  参考文献：
  名称：

  310.类固醇与Walden反演。第XLVII部分。5α-胆甾醇-1-酮，A-nor-5α-胆甾醇-1-酮及其一些衍生物

  摘要：

  DOI：

  10.1039/jr9610001583
• 作为产物：
  描述：

  5α-Cholestanon-oxim-(1) 在 戊醇 、 sodium 作用下， 生成 1ξ-Amino-5α-cholestan
  参考文献：
  名称：

  310.类固醇与Walden反演。第XLVII部分。5α-胆甾醇-1-酮，A-nor-5α-胆甾醇-1-酮及其一些衍生物

  摘要：

  DOI：

  10.1039/jr9610001583

文献信息

• [EN] DISRUPTORS OF EARLY/RECYCLING ENDOSOMES<br/>[FR] PERTURBATEURS DES ENDOSOMES PRÉCOCES/DE RECYCLAGE
  申请人：UNIV KANSAS

  公开号：WO2010022051A2

  公开（公告）日：2010-02-25

  A delivery system for introducing a cargo molecule into cytosol of a living cell can include: a first membrane binding element linked to an endosomal compartment disrupting element through a first linker having one or more anionic moieties; and a second membrane binding element linked to an exogenous cargo molecule through a second linker having one or more anionic moieties, the second linker having a region that is selectively cleavable, wherein the first and second membrane binding elements both induce endocytosis into an early/recycling endosome and the endosomal compartment disrupting element destabilizes the early/recycling endosome such that the exogenous cargo molecule is released from the second membrane binding element and into the cytosol of the living cell.
• [EN] SYNTHETIC CHOLESTERYLAMINE-LINKER DERIVATIVES FOR AGENT DELIVERY INTO CELLS<br/>[FR] DÉRIVÉS SYNTHÉTIQUES DE CHOLESTÉRYLAMINE-LIEUR POUR L'ADMINISTRATION INTRACELLULAIRE D'AGENTS
  申请人：UNIV KANSAS

  公开号：WO2011019942A2

  公开（公告）日：2011-02-17

  Synthetic cholesterylamine-linkers can include derivatives of cholesterol, cholesteryl, or sitosteryl coupled through the linker to an agent for delivery into cells. The cholesterylamines are thought to mimic cholesterol in the capacity and mechanism for enhanced entry into cells. The configuration of the cholesterylamine-linker that is thought to provide for enhanced entry into cells includes a cholesterylamine that is coupled to a linker from the amine, and which linker includes a negative charge at a spatial distance from the amine of the cholesterylamine.
• 310. Steroids and Walden inversion. Part XLVII. 5α-Cholestan-1-one,<scp>A</scp>-nor-5α-cholestan-1-one, and some derivatives thereof
  作者：C. W. Shoppee、S. K. Roy、B. S. Goodrich

  DOI：10.1039/jr9610001583

  日期：——