N,N'-二(3-乙基氨基丙基)庚烷-1,7-二胺 | 132004-62-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: N,N'-二(3-乙基氨基丙基)庚烷-1,7-二胺
• 英文名称: N,N'-bis[3-(ethylamino)propyl]-1,7-heptanediamine
• 英文别名: MDL 28314；N,N'-bis[3-(ethylamino)propyl]-1,7-diaminoheptane；N,N'-Bis(3-(ethylamino)propyl)-1,7-heptanediamine；N,N'-bis[3-(ethylamino)propyl]heptane-1,7-diamine
• CAS: 132004-62-7
• 化学式: C₁₇H₄₀N₄
• 分子量: 300.531
• InChiKey: WIOJAQYPAPCEMC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  21
• 可旋转键数：
  18
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  48.1
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N,N'-二(3-乙基氨基丙基)庚烷-1,7-二胺 、 3,7,15,19-tetra(t-butoxycarbonyl)-3,7,15,19-tetraazaheneicosane 、 盐酸 在 title compound 、 水合甲醇 作用下， 以 甲醇 为溶剂， 反应 16.0h， 以v/v) to yield 0.5 gm of the title compound的产率得到N,N'-二-(3-((苯基甲基)氨基)丙基)-1,8-二氨基辛烷
  参考文献：
  名称：

  Polyamine derivatives

  摘要：

  本发明涉及某些多胺衍生物，以及用于它们的制备的方法和中间体，以及它们在治疗由多种寄生原虫感染引起的疾病中的应用。

  公开号：

  US05753714A1
• 作为产物：
  描述：

  1,5,13,17-tetrakis(tert-butoxycarbonyl)-1,5,13,17-tetraazaheptadecane 生成 N,N'-二(3-乙基氨基丙基)庚烷-1,7-二胺
  参考文献：
  名称：

  Use of N,N'-bis 3-(ethylamino)propyl -1,7-heptanediamine and a cytotoxic agent

  摘要：

  本发明涉及将N,N'-双[3-(乙基氨基)丙基]-1,7-庚二胺与从抗肿瘤韦因卡生物碱、抗肿瘤抗生素、抗肿瘤抗代谢物和抗肿瘤铂配合物中选择的细胞毒性药物结合，用于制备一种药物组合物，可用于治疗患有肿瘤疾病状态的患者。

  公开号：

  EP0490380A2

文献信息

• Method of treating cancer by conjunctive therapy with
  申请人：Merrell Pharmaceuticals Inc.

  公开号：US05646124A1

  公开（公告）日：1997-07-08

  The present invention relates to a method of treating a patient suffering from a neoplastic disease state comprising administering to said patient an effective antineoplastic amount of N,N'-bis[3-(ethylamino)propyl]-1,7-heptanediamine in conjunctive therapy with an effective antineoplastic amount of a cytotoxic agent selected from the group consisting of an antineoplastic vinca alkaloid, an antineoplastic antibiotic, an antineoplastic antimetabolite and an antineoplastic platinum coordination complex, wherein a synergistic antineoplastic effect results.

  本发明涉及一种治疗患有肿瘤疾病状态的患者的方法，包括向该患者施用有效的抗肿瘤量的N,N'-双[3-(乙基氨基)丙基]-1,7-庚二胺和有效的抗肿瘤量的细胞毒性药物，所述细胞毒性药物选自抗肿瘤长春花生物碱、抗肿瘤抗生素、抗肿瘤抗代谢物和抗肿瘤铂配合物组，从而产生协同的抗肿瘤效应。
• Method of treating cancer by conjunctive therapy with N,N.sup.1
  申请人：Merrell Phamaceuticals Inc.

  公开号：US05654287A1

  公开（公告）日：1997-08-05

  The present invention relates to a method of treating a patient suffering from a neoplastic disease state comprising administering to said patient an effective antineoplastic amount of N,N'-bis[3-(ethylamino)propyl]-1,7-heptanediamine in conjunctive therapy with an effective antineoplastic amount of a cytotoxic agent selected from the group consisting of an antineoplastic vinca alkaloid, an antineoplastic antibiotic, an antineoplastic antimetabolite and an antineoplastic platinum coordination complex, wherein a synergistic antineoplastic effect results.

  本发明涉及一种治疗患有肿瘤疾病状态的患者的方法，包括向该患者施用有效的抗肿瘤量的N,N'-双[3-(乙基氨基)丙基]-1,7-庚二胺，与有效的抗肿瘤量的细胞毒素药物联合治疗，所述细胞毒素药物被选择自抗肿瘤长春花生物碱、抗肿瘤抗生素、抗肿瘤抗代谢物和抗肿瘤铂配合物的组中，从而产生协同的抗肿瘤效果。
• Polyamine derivatives as antineoplastic agents
  申请人：Merrell Dow Pharmaceuticals Inc.

  公开号：US05109024A1

  公开（公告）日：1992-04-28

  The present invention relates to certain novel polyamine compounds of the formula: ##STR1## wherein Z is a saturated (C.sub.2 -C.sub.6) alkylene moiety, each R group independently is hydrogen, methyl, ethyl, or n-propyl with the provisos that both R groups cannot be hydrogen and that R is hydrogen or methyl when Z is a branched chain alkylene; or a pharmaceutically acceptable acid addition salt thereof.

  本发明涉及某些新型聚胺化合物，其化学式为：##STR1## 其中Z是饱和的(C.sub.2 -C.sub.6)烷基亚烷基，每个R基团独立地是氢、甲基、乙基或正丙基，但有以下规定：两个R基团不能同时为氢，当Z是支链烷基时，R为氢或甲基；或其药学上可接受的酸加盐。
• NOVEL POLYAMINE ANALOG CONJUGATES AND QUINONE CONJUGATES AS THERAPIES FOR CANCERS AND PROSTATE DISEASES
  申请人：Frydman Benjamin

  公开号：US20080194697A1

  公开（公告）日：2008-08-14

  Peptide conjugates in which cytostatic and cytostatic agents, such as polyamine analogs or naphthoquinones, are conjugated to a polypeptide recognized and cleaved by enzymes such as prostate-specific antigen (PSA) and cathepsin B are provided, as well as compositions comprising these conjugates. Methods of using these conjugates in the treatment of prostate diseases are also provided.

  提供了肽共轭物，其中细胞生长抑制剂和细胞毒剂，如多胺类似物或萘醌，与多肽共轭，并被酶如前列腺特异性抗原（PSA）和半胱氨酸蛋白酶B识别和剪切，以及包含这些共轭物的组合物。还提供了使用这些共轭物治疗前列腺疾病的方法。
• Treatment and prevention of vascular hyperplasia using polyamine and polyamine analog compounds
  申请人：Marton J. Laurence

  公开号：US20070232677A1

  公开（公告）日：2007-10-04

  This disclosure relates to methods of inhibiting vascular hyperplasia using polyamines, polyamine analogs, and conformationally restricted polyamine analogs, or a conjugate of a polyamine, polyamine analog, or conformationally restricted polyamine analog. Polyamines, polyamine analogs, conformationally restricted polyamine analogs, and conjugates thereof are useful in reducing stenosis and restenosis of blood vessels and grafts.

  本公开涉及使用多胺，多胺类似物和构象限制多胺类似物或多胺，多胺类似物或构象限制多胺类似物的共轭物来抑制血管增生的方法。多胺，多胺类似物，构象限制多胺类似物及其共轭物在减少血管和移植物的狭窄和再狭窄方面非常有用。