7-(3-aminomethyl-3-methyl-4-fluoromethoxyimino-1-pyrrolidinyl)-1-cyclopropyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid | 1356857-81-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 7-(3-aminomethyl-3-methyl-4-fluoromethoxyimino-1-pyrrolidinyl)-1-cyclopropyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
• 英文别名: 7-[3-(aminomethyl)-4-(fluoromethoxyimino)-3-methylpyrrolidin-1-yl]-1-cyclopropyl-4-oxo-1,8-naphthyridine-3-carboxylic acid
• CAS: 1356857-81-2
• 化学式: C₁₉H₂₂FN₅O₄
• 分子量: 403.413
• InChiKey: RJKUFDOKWQLOAZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.51
• 重原子数：
  29.0
• 可旋转键数：
  6.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  123.04
• 氢给体数：
  2.0
• 氢受体数：
  8.0

反应信息

• 作为产物：
  描述：

  7-(3-((benzylideneamino)methyl)-4-((fluoromethoxy)imino)-3-methylpyrrolidin-1-yl)-1-cyclopropyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid 在 silica gel 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 生成 7-(3-aminomethyl-3-methyl-4-fluoromethoxyimino-1-pyrrolidinyl)-1-cyclopropyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
  参考文献：
  名称：

  Synthesis and antibacterial activity of naphthyridone derivatives containing mono/difluoro-methyloxime pyrrolidine scaffolds

  摘要：

  A series of novel naphthyridone derivatives containing mono/difluoro-methyloxime pyrrolidine scaffolds were designed and synthesized. These derivatives were initially evaluated for their in vitro antibacterial activity and compounds 13a1, b1 were chosen for further evaluation their in vivo activity against systemic infections in mice. The results indicate that all of the target compounds have considerable in vitro antibacterial activity. In the in vivo experiments, 13b1 was found to be more effective than the parent drug gemifloxacin against the tested five strains, and especially its activity (ED50:21.27 mg/kg) is 5.2-6.1 times more potent than gemifloxacin and ciprofloxacin against clinically important Gram-negative pathogen Pseudomonas aeruginosa. (C) 2011 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2011.10.048

文献信息

• Synthesis and antibacterial activity of naphthyridone derivatives containing mono/difluoro-methyloxime pyrrolidine scaffolds
  作者：Kai Lv、Ming-Liang Liu、Lian-Shun Feng、Lan-Ying Sun、Ye-Xin Sun、Zeng-Quan Wei、Hui-Quan Guo

  DOI：10.1016/j.ejmech.2011.10.048

  日期：2012.1

  A series of novel naphthyridone derivatives containing mono/difluoro-methyloxime pyrrolidine scaffolds were designed and synthesized. These derivatives were initially evaluated for their in vitro antibacterial activity and compounds 13a1, b1 were chosen for further evaluation their in vivo activity against systemic infections in mice. The results indicate that all of the target compounds have considerable in vitro antibacterial activity. In the in vivo experiments, 13b1 was found to be more effective than the parent drug gemifloxacin against the tested five strains, and especially its activity (ED50:21.27 mg/kg) is 5.2-6.1 times more potent than gemifloxacin and ciprofloxacin against clinically important Gram-negative pathogen Pseudomonas aeruginosa. (C) 2011 Elsevier Masson SAS. All rights reserved.