2-acetamido-7-methoxy-1,2,3,4-tetrahydronaphthalene | 121454-60-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 2-acetamido-7-methoxy-1,2,3,4-tetrahydronaphthalene
• 英文别名: 7-methoxy-2-acetamido-tetralin；N-(7-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)-acetamide；N-(7-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)acetamide
• CAS: 121454-60-2
• 化学式: C₁₃H₁₇NO₂
• 分子量: 219.283
• InChiKey: YLSJLYYBVHQMEQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-acetamido-7-methoxy-1,2,3,4-tetrahydronaphthalene 生成 N-(1,2,3,4-四氢-7-羟基-2-萘基)乙酰胺
  参考文献：
  名称：

  PEGLION, JEAN-LOUIS;POIGNANT, JEAN-CLAUDE;VIAN, JOEL

  摘要：

  DOI：
• 作为产物：
  描述：

  (NZ)-N-(7-methoxy-3,4-dihydro-1H-naphthalen-2-ylidene)hydroxylamine 生成 2-acetamido-7-methoxy-1,2,3,4-tetrahydronaphthalene
  参考文献：
  名称：

  PEGLION, JEAN-LOUIS;POIGNANT, JEAN-CLAUDE;VIAN, JOEL

  摘要：

  DOI：

文献信息

• Process for the preparation of substituted tetralin and substituted indane derivatives
  申请人：Zhang-Plasket Fan

  公开号：US20050240049A1

  公开（公告）日：2005-10-27

  The present invention relates to novel processes for the preparation of substituted tetralin. and substituted indane derivatives. The present invention is further directed to novel processes for the preparation of intermediates in the preparation of the substituted tetralin and substituted indane derivatives.

  本发明涉及一种制备取代四氢萘和取代茚衍生物的新工艺。本发明还涉及一种用于制备取代四氢萘和取代茚衍生物中间体的新工艺。
• [EN] PROCESS FOR THE PREPARATION OF SUBSTITUTED TETRALIN AND SUBSTITUTED INDANE DERIVATIVES<br/>[FR] PROCEDES DE PREPARATION DE DERIVES DE TETRALINE SUBSTITUEE ET D'INDANE SUBSTITUE
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2005105737A1

  公开（公告）日：2005-11-10

  The present invention relates to novel processes for the preparation of substituted tetralin and substituted indane derivatives. The present invention is further directed to novel processes for the preparation of intermediates in the preparation of the substituted tetralin and substituted indane derivatives.

  本发明涉及一种新的制备取代四氢萘和取代茚烷衍生物的过程。本发明还涉及制备取代四氢萘和取代茚烷衍生物中间体的新过程。
• Substituted 2-amidotetralins as melatonin agonists and antagonists
  申请人：Northwestern University

  公开号：US05151446A1

  公开（公告）日：1992-09-29

  The present invention relates generally to compounds having melatonin receptor activities and in particular to substituted 2-amidotetralin derivatives; to pharmaceutical preparations comprising such compounds; and to methods for using these compounds as therapeutic and diagnostic reagents.

  本发明涉及具有褪黑激素受体活性的化合物，特别是取代的2-氨基四氢萘衍生物；包括含有这种化合物的药物制剂；以及使用这些化合物作为治疗和诊断试剂的方法。
• PROCESS FOR THE PREPARATION OF SUBSTITUTED TETRALIN AND SUBSTITUTED INDANE DERIVATIVES
  申请人：Zhan-Plasket Fan

  公开号：US20090326258A1

  公开（公告）日：2009-12-31

  The present invention relates to novel processes for the preparation of substituted tetralin and substituted indane derivatives. The present invention is further directed to novel processes for the preparation of intermediates in the preparation of the substituted tetralin and substituted indane derivatives.

  本发明涉及制备取代四氢萘和取代茚烷衍生物的新型工艺。本发明还涉及制备取代四氢萘和取代茚烷衍生物的中间体的新型工艺。
• Process for the Preparation of Substituted Tetralin and Substituted Indane Derivatives
  申请人：Zhang-Plasket Fan

  公开号：US20080096962A1

  公开（公告）日：2008-04-24

  The present invention relates to novel processes for the preparation of substituted tetralin and substituted indane derivatives. The present invention is further directed to novel processes for the preparation of intermediates in the preparation of the substituted tetralin and substituted indane derivatives.

  本发明涉及一种制备取代四氢萘和取代茚烷衍生物的新工艺。本发明进一步涉及一种制备取代四氢萘和取代茚烷衍生物的中间体的新工艺。