5-Methyl-5β-cholest-3-en | 23931-38-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 5-Methyl-5β-cholest-3-en
• 英文别名: (5R,8S,9S,10R,13R,14S,17R)-5,10,13-trimethyl-17-[(2R)-6-methylheptan-2-yl]-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthrene
• CAS: 23931-38-6
• 化学式: C₂₈H₄₈
• 分子量: 384.689
• InChiKey: KXQDBSYEAFGYIS-CCDATYBZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.9
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  5-Methyl-5β-cholest-3-en 生成 5β-Methyl-A-norcholestan-3-on
  参考文献：
  名称：

  A-全胆甾-3-酮的光产物的合成和X射线结构测定。

  摘要：

  DOI：

  10.1021/jo00913a013
• 作为产物：
  描述：

  5-胆甾烯-3-酮 、 甲基锂 生成 5-Methyl-5β-cholest-3-en
  参考文献：
  名称：

  Reduction of enol phosphates to alkenes with titanium metal

  摘要：

  DOI：

  10.1021/jo00407a041

文献信息

• Design, synthesis, application and recovery of a minimally fluorous diaryl diselenide for the catalysis of stannane-mediated radical chain reactions
  作者：David Crich、Xiaolin Hao、Mathew Lucas

  DOI：10.1016/s0040-4020(99)00902-3

  日期：1999.12

  diselenide is described. On reduction in situ with tributylstannane this diselenide provides a fluorous selenol which is effective in inhibiting a range of stannane-mediated radical rearrangements, including a cyclopropylcarbinyl ring opening. A method for the recovery of the fluorous diselenide involving continuous extraction in a modified, cooled continuous extractor is described.

  描述了最低氟（52％F）二芳基二硒化物的合成。在用三丁基锡烷原位还原时，该二硒化物提供了一种氟硒醇，其有效抑制了由锡烷介导的自由基重排的范围，包括环丙基羰基的开环。描述了一种回收二硒氟的方法，该方法包括在改良的冷却的连续萃取器中连续萃取。
• Inhibition of Stannane-Mediated Radical Rearrangements by a Recoverable, Minimally Fluorous Selenol
  作者：David Crich、Xiaolin Hao、Mathew A. Lucas

  DOI：10.1021/ol990590+

  日期：1999.7.1

  [GRAPHICS]The preparation of a minimally fluorous diaryl diselenide is described. It is demonstrated that this diselenide, reduced in situ to the corresponding selenol, may be used in conjunction with stannanes to prevent a number of radical rearrangements. A 1 M solution of this selenol used in admixture with Breslow's water-soluble stannane can be used to significantly inhibit a cyclopropylcarbinyl ring opening. The combination of the fluorous selenol and the polar stannane permits recovery of the selenol by continuous fluorous extraction and isolation of a stannane-free hydrocarbon product.
• Reduction of enol phosphates to alkenes with titanium metal
  作者：Steven C. Welch、Marlin E. Walters

  DOI：10.1021/jo00407a041

  日期：1978.6
• Synthesis and x-ray structure determination of the photoproducts of A-homocholestan-3-one
  作者：T. Akiyama、D. Pedder、J. V. Silverton、J. I. Seeman、H. Ziffer

  DOI：10.1021/jo00913a013

  日期：1975.12