(Z)-4-[2-(4-chlorophenyl)vinyl]biphenyl | 1395063-57-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: (Z)-4-[2-(4-chlorophenyl)vinyl]biphenyl
• 英文别名: (Z)-4-(4-(chlorostyryl)biphenyl)；1-chloro-4-[(Z)-2-(4-phenylphenyl)ethenyl]benzene
• CAS: 1395063-57-6
• 化学式: C₂₀H₁₅Cl
• 分子量: 290.792
• InChiKey: AMLKOQGVFVNSGO-SREVYHEPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  (E)-1-bromo-4-(4-chlorostyryl)benzene 、 苯硼酸 在 1-[(二甲基氨基)(苯基)甲基]-2-萘酚 、 四丁基溴化铵 、 palladium diacetate 、 potassium carbonate 作用下， 以 N,N-二甲基乙酰胺 为溶剂， 反应 24.0h， 生成 (Z)-4-[2-(4-chlorophenyl)vinyl]biphenyl 、 (E)-4-[2-(4-chlorophenyl)vinyl]biphenyl
  参考文献：
  名称：

  1-(α-Aminobenzyl)-2-naphthol as phosphine-free ligand for Pd-catalyzed Suzuki and one-pot Wittig-Suzuki reaction

  摘要：

  Air stable and easily accessible, 1‐(α‐aminobenzyl)‐2‐naphthols are used as efficient phosphine‐free ligands in palladium‐catalyzed Suzuki reaction for a variety of substrates under conventional heating as well as ultrasonic conditions. Multi‐brominated aromatic substrates were successfully converted to corresponding arylated moieties with good conversion and selectivity. A novel one‐pot two‐step cascade reaction strategy involving Wittig and Suzuki reactions is developed for efficient synthesis of 4‐styryl biphenyls (C6‐C2‐C6‐C6 unit). Copyright © 2012 John Wiley & Sons, Ltd.

  DOI：

  10.1002/aoc.2877

文献信息

• 1-(α-Aminobenzyl)-2-naphthol as phosphine-free ligand for Pd-catalyzed Suzuki and one-pot Wittig-Suzuki reaction
  作者：A. R. Chaudhary、A. V. Bedekar

  DOI：10.1002/aoc.2877

  日期：2012.8

  Air stable and easily accessible, 1‐(α‐aminobenzyl)‐2‐naphthols are used as efficient phosphine‐free ligands in palladium‐catalyzed Suzuki reaction for a variety of substrates under conventional heating as well as ultrasonic conditions. Multi‐brominated aromatic substrates were successfully converted to corresponding arylated moieties with good conversion and selectivity. A novel one‐pot two‐step cascade reaction strategy involving Wittig and Suzuki reactions is developed for efficient synthesis of 4‐styryl biphenyls (C6‐C2‐C6‐C6 unit). Copyright © 2012 John Wiley & Sons, Ltd.