N,N-二甲基-2-十四烷胺N-氧化物 | 13025-82-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: N,N-二甲基-2-十四烷胺N-氧化物
• 英文名称: 2-Tetradecanamine, N,N-dimethyl-, N-oxide
• 英文别名: N,N-dimethyltetradecan-2-amine oxide
• CAS: 13025-82-6
• 化学式: C16H35NO
• 分子量: 257.45
• InChiKey: MCCDQLDGOIFDGF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  18
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  18.1
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• Phenylacetonitrile derivatives and hair tonics and external preparations for skin containing the derivatives
  申请人：Hanyu Naoto

  公开号：US20050176822A1

  公开（公告）日：2005-08-11

  A hair growth promoting composition comprising, as an effective ingredient, a phenylacetonitrile derivative or a pharmacologically acceptable salt thereof expressed by the following Formula (I): wherein each of R 1 and R 2 is hydrogen atom, a C 1-10 alkyl group, a C 2-10 alkenyl group or C 2-10 acyl group, or NR 1 R 2 may be a heterocycle having 3-7 members; R 3 is a C 1-5 alkyl group; and each of R 4 , R 5 and R 6 is hydrogen atom or a C 1-4 alkoxy group. The present invention provides a hair growth promoting composition having excellent effects on promoting hair regrowth, preventing or inhibiting hair loss, and the like in human by compounding above-specified phenylacetonitrile derivative as a effective ingredient thereto.

  一种促进头发生长的组合物，包括以下式子（I）表示的苯乙腈衍生物或其药学上可接受的盐作为有效成分：其中R1和R2中的每一个均为氢原子，C1-10烷基，C2-10烯基或C2-10酰基，或者NR1R2可以是具有3-7个成员的杂环；R3为C1-5烷基；R4、R5和R6中的每一个均为氢原子或C1-4烷氧基。本发明提供了一种促进头发再生、预防或抑制脱发等在人体上具有优异效果的头发生长促进组合物，其中上述苯乙腈衍生物作为有效成分混合在其中。
• 1,2-Di-substituted piperidine derivatives as hair growth promoter
  申请人：SHISEIDO COMPANY LIMITED

  公开号：EP0933361A1

  公开（公告）日：1999-08-04

  A 1,2-di-substituted piperidine derivative or a salt thereof expressed by the following Formula (I): wherein one of A and B is a hydrocarbon group of C1-30 expressed by R1 and the other is -(CH2)n-NR2R3; Y is -CO-, -CONR5- or -COO-; Z is -O-, -OCO-, -OCONR6- or -NR6-; R2 and R3 individually represent a hydrogen a lower alkyl, a phenyl or a benzyl group, or together represent a heterocycle having 3-7 members; -NR5-(CH2)n-NR2R3 and -NR6-(CH2)n-NR2R3 of -(Y)1-A and -Z-B may be the following Group W: wherein ring E is a heterocycle of 6 or 7 members including two nitrogen atoms and R2 is a hydrogen, a lower alkyl, a phenyl or a benzyl group; R4 is a hydrogen, a halogen, a lower alkyl, a lower acyl, a nitro, a cyano, a lower alkoxycarbonyl, a carbamoyl, a lower alkylcarbamoyl, a lower alkylamino, a lower acylamino, a lower alkoxy or a lower acyloxy group; each of R5 and R6 is a hydrogen, a lower alkyl, a lower acyl, a lower alkylcarbamoyl group, or a part of said ring E; l is 0 or 1; m is an integer of 2-5; and n is an integer of 0-5. The 1,2-di-substituted piperidine derivative or the salt thereof has excellent hair growth and regrowth promoting effects, which are useful for care, improvement or prevention of hair loss in mammals and, in particular, in human.

  一种 1,2-二取代的哌啶衍生物或其盐，由下式（I）表示： 其中 A 和 B 中的一个是由 R1 表示的 C1-30 的烃基，另一个是-(CH2)n-NR2R3；Y 是-CO-、-CONR5- 或-COO-；Z 是-O-、-OCO-、-OCONR6- 或-NR6-；R2 和 R3 分别代表氢、低级烷基、苯基或苄基，或共同代表具有 3-7 个成员的杂环；-(Y)1-A 和-Z-B 的-NR5-(CH2)n-NR2R3 和-NR6-(CH2)n-NR2R3 可以是以下 W 组： 其中环 E 是包括两个氮原子的 6 或 7 个成员的杂环，R2 是氢、低级烷基、苯基或苄基；R4 是氢、卤素、低级烷基、低级酰基、硝基、氰基、低级烷氧羰基、氨基甲酰基、低级烷基氨基甲酰基、低级烷氨基、低级酰氨基、低级烷氧基或低级酰氧基；R5和R6各自为氢、低级烷基、低级酰基、低级烷基氨基甲酰基或所述环E的一部分；l为0或1；m为2-5的整数；n为0-5的整数。1,2-二取代哌啶衍生物或其盐具有良好的促进毛发生长和再生的效果，可用于护理、改善或预防哺乳动物，尤其是人类的脱发。
• 6- (Substituted-methyl) -3- cyclohexenyl formamide derivative, hair growth promoter and external composition for skin
  申请人：SHISEIDO COMPANY LIMITED

  公开号：EP0940390A1

  公开（公告）日：1999-09-08

  A [6-(substituted-methyl)-3-cyclohexenyl]formamide derivative or a salt thereof expressed by the following Formula (I): wherein one of A and B is a hydrocarbon group of C10-30 expressed by R1 and the other is - (CH)n-NR2R3; Z is -O-, -OCO-, -OCONR6- or -NR6-; R2 and R3 individually represent a hydrogen, lower alkyl, phenyl or benzyl group, or together represent a heterocycle having 3-7 members; -NR5-(CH)n-NR2R3 or -NR6-(CH)n-NR2R3 may be Group W, and -OCONR6-(CH)n-NR2R3 may be -OCO-W, wherein W is a formula of: wherein ring E is a heterocycle of 6 or 7 members including two nitrogen atoms and R2 is a hydrogen, lower alkyl, phenyl or benzyl group; R4 is a halogen, lower alkyl, lower acyl, nitro, cyano, lower alkoxycarbonyl, carbamoyl, lower alkylcarbamoyl, lower alkylamino, lower acylamino, lower alkoxy or lower acyloxy group; each of R5 and R6 is a hydrogen, lower alkyl, lower acyl, lower alkylcarbamoyl group, or a part of said Group W; m is an integer of 0-2; and n is an integer of 0-5. The [6-(substituted-methyl)-3-cyclohexenyl]formamide derivative or the salt thereof has excellent hair growth and regrowth promoting effects, which are useful for care, improvement or prevention of hair loss in mammals and, in particular, in human.

  一种[6-(取代-甲基)-3-环己烯基]甲酰胺衍生物或其盐，由下式(I)表示： 其中 A 和 B 中的一个是由 R1 表示的 C10-30 的烃基，另一个是-(CH)n-NR2R3；Z 是-O-、-OCO-、-OCONR6- 或-NR6-；R2 和 R3 分别代表氢、低级烷基、苯基或苄基，或共同代表具有 3-7 个成员的杂环；-NR5-(CH)n-NR2R3 或 -NR6-(CH)n-NR2R3 可以是 W 组，而 -OCONR6-(CH)n-NR2R3 可以是 -OCO-W，其中 W 的式子为： 其中环 E 是包括两个氮原子的 6 或 7 个成员的杂环，R2 是氢、低级烷基、苯基或苄基；R4 是卤素、低级烷基、低级酰基、硝基、氰基、低级烷氧羰基、氨基甲酰基、低级烷基氨基甲酰基、低级烷氨基、低级酰氨基、低级烷氧基或低级酰氧基；R5 和 R6 中的每一个是氢、低级烷基、低级酰基、低级烷基氨基甲酰基或所述 W 组的一部分；m 是 0-2 的整数；n 是 0-5 的整数。6-(取代-甲基)-3-环己烯基]甲酰胺衍生物或其盐具有良好的促进毛发生长和再生的效果，可用于护理、改善或预防哺乳动物，尤其是人类的脱发。
• Benzimidazole derivative, hair growth promoter and external composition for skin using the same
  申请人：SHISEIDO COMPANY LIMITED

  公开号：EP0989123A1

  公开（公告）日：2000-03-29

  A benzimidazole derivative or a salt thereof expressed by the following Formula (I): wherein one of A and B is a hydrocarbon group of C10-30 expressed by R1 and the other is -(CH2)n-NR2R3; R2 and R3 individually represent H, lower alkyl, phenyl or benzyl, or -NR2R3 may be a heterocycle having 3-7 members, or -CONR5-(CH2)n-NR2R3 may be the following Group (W): wherein R2 is H, lower alkyl, phenyl or benzyl and ring E is a heterocycle of 6 or 7 members; R4 is selected from the group consisting of H, halogen, cyano, trifluoromethyl, lower alkyl and etc.; R5 is H, lower alkyl, lower acyl or lower alkylcarbamoyl; m is 0 or 1; and n is an integer of 0-5. The benzimidazole derivative or the salt thereof has excellent hair growth and regrowth promoting effects, which are useful for care, improvement or prevention of hair loss in mammals and, in particular, in human.

  由下式（I）表示的苯并咪唑衍生物或其盐： 其中 A 和 B 中的一个是由 R1 表示的 C10-30 的烃基，另一个是-(CH2)n-NR2R3；R2 和 R3 分别代表 H、低级烷基、苯基或苄基，或-NR2R3 可以是具有 3-7 个成员的杂环，或-CONR5-(CH2)n-NR2R3 可以是下式（W）： 其中 R2 是 H、低级烷基、苯基或苄基，环 E 是具有 6 或 7 个成员的杂环；R4 选自 H、卤素、氰基、三氟甲基、低级烷基等组成的组；R5 是 H、低级烷基、低级酰基或低级烷基氨基甲酰基；m 是 0 或 1；n 是 0-5 的整数。苯并咪唑衍生物或其盐具有良好的促进毛发生长和再生的效果，可用于护理、改善或预防哺乳动物，尤其是人类的脱发。
• (2-oxy substituted)-phenylalkanamide derivative, hair growth promoter and external composition for skin using the same
  申请人：SHISEIDO COMPANY LIMITED

  公开号：EP1026150A1

  公开（公告）日：2000-08-09

  A (2-substituted oxyphenyl)alkanamide derivative or a salt thereof expressed by the following Formula (I): wherein one of A and B is a hydrocarbon group of C3-30 expressed by R1 and the other is -(CH2)n-NR2R3; Z is -CO- or -CONR6-; R2 and R3 individually represent H, lower alkyl or benzyl, or -NR2R3 may be a heterocycle having 3-7 members; wherein -CONR5-(CH2)n-NR2R3 or -CONR6-(CH2)n-NR2R3 may be the following Group (II): wherein ring Y is a heterocycle of 6 or 7 members; R4 is selected from the group consisting of H, halogen, lower alkyl, lower acyl and etc; R5 and R6 are individually H, lower alkyl, lower acyl or lower alkylcarbamoyl, or may form a part of said Group(II); l is 0 or 1; m is 1 or 2; and n is an integer of 0-5. The (2-substituted oxyphenyl)alkanamide derivative or the salt thereof has excellent hair growth and regrowth promoting effects, which are useful for care, improvement or prevention of hair loss in mammals and, in particular, in human.

  下式(I)表示的(2-取代氧基苯基)烷酰胺衍生物或其盐： 其中 A 和 B 中的一个是由 R1 表示的 C3-30 的烃基，另一个是-(CH2)n-NR2R3； Z 是-CO- 或-CONR6-； R2 和 R3 分别代表 H、低级烷基或苄基，或-NR2R3 可以是具有 3-7 个成员的杂环； 其中-CONR5-(CH2)n-NR2R3 或-CONR6-(CH2)n-NR2R3 可以是下式(II)： 其中环 Y 是由 6 或 7 个成员组成的杂环；R4 选自 H、卤素、低级烷基、低级酰基等组成的组；R5 和 R6 单独为 H、低级烷基、低级酰基或低级烷基氨基甲酰基，或可构成所述基团（II）的一部分；l 为 0 或 1；m 为 1 或 2；n 为 0-5 的整数。(2-取代氧苯基)烷酰胺衍生物或其盐具有良好的促进毛发生长和再生的效果，可用于护理、改善或预防哺乳动物，尤其是人类的脱发。