4-Hexoxy-1-methoxy-2,2,6,6-tetramethylpiperidine | 1206873-25-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 4-Hexoxy-1-methoxy-2,2,6,6-tetramethylpiperidine
• 英文别名: 4-hexoxy-1-methoxy-2,2,6,6-tetramethylpiperidine
• CAS: 1206873-25-7
• 化学式: C₁₆H₃₃NO₂
• 分子量: 271.444
• InChiKey: FXFQJRXKJKODQW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  21.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  octa acid 、 4-Hexoxy-1-methoxy-2,2,6,6-tetramethylpiperidine 在 Sodium tetraborate decahydrate 作用下， 以 water-d2 为溶剂， 生成
  参考文献：
  名称：

  Chemistry in Confined Spaces: High-Energy Conformer of a Piperidine Derivative is Favored Within a Water-Soluble Capsuleplex

  摘要：

  Propyloxy-substituted piperidine in solution adopts a conformation in which its alkoxy group is equatorially positioned Surprisingly, two conformers of it that do not interconvert in the NMR time scale at room temperature have been found within an octa-acid capsule The serendipitous finding of the axial conformer of propyloxy-substituted piperidine within a supramolecular capsule highlights the value of confined spaces in physical organic chemistry.

  DOI：

  10.1021/ol101841n
• 作为产物：
  描述：

  阻聚剂701 、 溴己烷 、 甲基锂 在 sodium hydride 作用下， 以 四氢呋喃 、 mineral oil 、 乙醚 为溶剂， 反应 52.5h， 生成 4-Hexoxy-1-methoxy-2,2,6,6-tetramethylpiperidine
  参考文献：
  名称：

  Chemistry in Confined Spaces: High-Energy Conformer of a Piperidine Derivative is Favored Within a Water-Soluble Capsuleplex

  摘要：

  Propyloxy-substituted piperidine in solution adopts a conformation in which its alkoxy group is equatorially positioned Surprisingly, two conformers of it that do not interconvert in the NMR time scale at room temperature have been found within an octa-acid capsule The serendipitous finding of the axial conformer of propyloxy-substituted piperidine within a supramolecular capsule highlights the value of confined spaces in physical organic chemistry.

  DOI：

  10.1021/ol101841n

文献信息

• Chemistry in Confined Spaces: High-Energy Conformer of a Piperidine Derivative is Favored Within a Water-Soluble Capsuleplex
  作者：Mintu Porel、Nithyanandhan Jayaraj、S. Raghothama、V. Ramamurthy

  DOI：10.1021/ol101841n

  日期：2010.10.15

  Propyloxy-substituted piperidine in solution adopts a conformation in which its alkoxy group is equatorially positioned Surprisingly, two conformers of it that do not interconvert in the NMR time scale at room temperature have been found within an octa-acid capsule The serendipitous finding of the axial conformer of propyloxy-substituted piperidine within a supramolecular capsule highlights the value of confined spaces in physical organic chemistry.